Influence of Co content on the system mother-placenta-fetus-newborn children born with hypoxia. Determination of microelement (ME) performed in serum and erythrocytes 30 pregnant women and their infants who have suffered asphyxia at birth. Comparison group consisted of 30 healthy women and their 30 healthy full-term infants

Kasyan, S.V.

Nwokie, Оbinna

Tarasova, Iryna Vitaliivna

Тарасова, Ирина Витальевна

Тарасова, Ірина Віталіївна

Electronic Sumy State University Institutional Repository

 1  Міністерство освіти та науки, молоді та спорту України Міністерство охорони здоров’я Сумський державний університет Медичний інституту         АКТУАЛЬНІ ПИТАННЯ ТЕРЕТИЧНОЇ ТА ПРАКТИЧНОЇ МЕДИЦИНИ  Topical Issues of Clinical and Theoretical Medicine        Збірник тез доповідей  ІІІ Міжнародної науково-практичної конференції Студентів та молодих вчених (Суми, 23-24 квітня 2015 року)      Суми Сумський державний університет 2015    282 ПЕДІАТРІЯ З ДИТЯЧИМИ ІНФЕКЦІЯМИ resolves by 3-4 months of age, generally supportive care; drug-induced neutropenia:  normal bone marrow reserve, but has been associated with a late maturational arrest, antibody or complement mediated neutrophil destruction, treatment consists of stopping unnecessary medications; infection related neutropenia:  normal bone marrow reserve, virus induced anti-neutrophil antibody; parvovirus B19 and HIV can be screened, no treatment generally necessary; hypersplenism:  normal bone marrow reserve, sequestration/possible destruction of neutrophils in the spleen,  associated with malaria, TB, neoplasm, collagen-vascular diseases, hemolytic anemia, spherocytes and tailed RBC on blood smear, treat underlying disorder; pseudo-neutropenia (severe infection):  normal bone marrow reserve; generally associated with increases in marginated and tissue pools, mild and spontaneously resolves; Shwachman-Diamond Syndrome:  primary decrease in bone marrow reserve, AR, S, extremely rare, steatorrhea from exocrine pancreatic deficiency, metaphyseal dysplasia, 50% survival; 1/3 progress to myelodysplastic syndrome or acute myeloid leukemia, normal sweat chloride; chemotherapy:  direct toxicity to neutrophil precursors results in a severe reduction in bone marrow reserve (severity dependent on the intensity of chemotherapy agents used), generally a high risk of infection with poor marrow reserve and generalized suppression of the immune system.   CONTENT OF COBALT IN BIOLOGICAL FLUIDSOFFULL-TERM NEWBORNS AS THE PREDICTOR OF PERINATAL HYPOXIC DAMAGE OF CNS I.V.Тarasova, SM.Kasyan, Nwokie Оbinnа Mentor – Associate Professor Tarasova I.V. Sumy State University, Department of Pediatrics with Medical Genetics Influence of Co content on the system mother-placenta-fetus-newborn children born with hypoxia. Determination of microelement (ME) performed in serum and erythrocytes 30 pregnant women and their infants who have suffered asphyxia at birth. Comparison group consisted of 30 healthy women and their 30 healthy full-term infants. The content of trace elements in biomaterials newborns and their mothers was determined by atomic absorption spectrophotometry mass spectrophotometer C-115M1, manufacturing NPO "Selmi" (Ukraine).  In the placenta of women who gave birth to children with hypoxia observed deficit Co, which creates conditions for faster penetration him to the fetus, but at the same time accumulation feature is suppressed. Serum and red blood cells of pregnant women who gave birth to children with CNS observed a significant lack of cobalt. We also investigated the features of ME content in serum and erythrocytes and especially their renal excretion in term neonates who underwent perinatal hypoxic of the CNS. These children in neonatal there a significant imbalance of serum and erythrocyte content Co. One of the factors of this imbalance ME if perinatal hypoxic of   the  CNS  in term infants is inhibition of excretion of ME. It is proved that an imbalance of serum and erythrocyte Co content in the body of the fetus and newborn, resulting in reduction of Co pregnant women  and  dysfunction  placental hypoxia.  Predictors  properties  of  Co  detected  in serum ≥3,01 mmol/l in erythrocytes ≥0,61 mg / mg ash and urine ≤0,40 mmol / l, respectively. Prognostic significance (index of informing and prognostic factor) was high.   THE VIOLATIONS OF NEURO-MENTAL DEVELOPMENT OF CHILDREN WHO HAVE SUFFERED FROM PERINATAL HYPOXIC DAMAGE OF CENTRAL NERVOUS SYSTEM I.V.Тarasova, SM.Kasyan, M.L. Radchenco, Akinjolire Oluwagbenga John Sumy State University, Department of Pediatrics with Medical Genetics The problem of children adaptation who suffered from perinatal hypoxic damage (PHD) of the central nervous system (CNS) is very important. The brain damage on the early stages of ontogeny violates deterministic evolutionary scenario of pre-, intra-and postnatal adaptation, slows ripening of parameters of functional CNS, which increase the likelihood of developing of secondary cerebral defects. The effects of PHD of CNS reflect not only the severity of injuries, but the effectivenes of 

Content of cobalt in biological fluidsoffull-term newborns as the predictor of perinatal hypoxic damage of CNS

SocioEconomic Challenges Journal (Sumy State University)

 
1  
Міністерство освіти та науки, молоді та спорту України 
Міністерство охорони здоров’я 
Сумський державний університет 
Медичний інституту 
 
 
 
 
 
 
 
 
АКТУАЛЬНІ ПИТАННЯ ТЕРЕТИЧНОЇ ТА 
ПРАКТИЧНОЇ МЕДИЦИНИ 
 
Topical Issues of Clinical and Theoretical 
Medicine 
 
 
 
 
 
 
 
Збірник тез доповідей  
ІІІ Міжнародної науково-практичної конференції 
Студентів та молодих вчених 
(Суми, 23-24 квітня 2015 року) 
 
 
 
 
 
Суми 
Сумський державний університет 
2015 
  
 
282 ПЕДІАТРІЯ З ДИТЯЧИМИ ІНФЕКЦІЯМИ 
resolves by 3-4 months of age, generally supportive care; drug-induced neutropenia:  normal bone 
marrow reserve, but has been associated with a late maturational arrest, antibody or complement 
mediated neutrophil destruction, treatment consists of stopping unnecessary medications; infection 
related neutropenia:  normal bone marrow reserve, virus induced anti-neutrophil antibody; parvovirus 
B19 and HIV can be screened, no treatment generally necessary; hypersplenism:  normal bone 
marrow reserve, sequestration/possible destruction of neutrophils in the spleen,  associated with 
malaria, TB, neoplasm, collagen-vascular diseases, hemolytic anemia, spherocytes and tailed RBC 
on blood smear, treat underlying disorder; pseudo-neutropenia (severe infection):  normal bone 
marrow reserve; generally associated with increases in marginated and tissue pools, mild and 
spontaneously resolves; Shwachman-Diamond Syndrome:  primary decrease in bone marrow reserve, 
AR, S, extremely rare, steatorrhea from exocrine pancreatic deficiency, metaphyseal dysplasia, 50% 
survival; 1/3 progress to myelodysplastic syndrome or acute myeloid leukemia, normal sweat 
chloride; chemotherapy:  direct toxicity to neutrophil precursors results in a severe reduction in bone 
marrow reserve (severity dependent on the intensity of chemotherapy agents used), generally a high 
risk of infection with poor marrow reserve and generalized suppression of the immune system. 
 
 
CONTENT OF COBALT IN BIOLOGICAL FLUIDSOFFULL-TERM NEWBORNS AS 
THE PREDICTOR OF PERINATAL HYPOXIC DAMAGE OF CNS 
I.V.Тarasova, SM.Kasyan, Nwokie Оbinnа 
Mentor – Associate Professor Tarasova I.V. 
Sumy State University, Department of Pediatrics with Medical Genetics 
Influence of Co content on the system mother-placenta-fetus-newborn children born with 
hypoxia. Determination of microelement (ME) performed in serum and erythrocytes 30 pregnant 
women and their infants who have suffered asphyxia at birth. Comparison group consisted of 30 
healthy women and their 30 healthy full-term infants. The content of trace elements in biomaterials 
newborns and their mothers was determined by atomic absorption spectrophotometry mass 
spectrophotometer C-115M1, manufacturing NPO "Selmi" (Ukraine).  
In the placenta of women who gave birth to children with hypoxia observed deficit Co, which 
creates conditions for faster penetration him to the fetus, but at the same time accumulation feature is 
suppressed. Serum and red blood cells of pregnant women who gave birth to children with CNS 
observed a significant lack of cobalt. We also investigated the features of ME content in serum and 
erythrocytes and especially their renal excretion in term neonates who underwent perinatal hypoxic 
of the CNS. These children in neonatal there a significant imbalance of serum and erythrocyte content 
Co. One of the factors of this imbalance ME if perinatal hypoxic of   the  CNS  in term infants is 
inhibition of excretion of ME. It is proved that an imbalance of serum and erythrocyte Co content in 
the body of the fetus and newborn, resulting in reduction of Co pregnant women  and  dysfunction  
placental hypoxia.  Predictors  properties  of  Co  detected  in serum ≥3,01 mmol/l in erythrocytes 
≥0,61 mg / mg ash and urine ≤0,40 mmol / l, respectively. Prognostic significance (index of informing 
and prognostic factor) was high. 
 
 
THE VIOLATIONS OF NEURO-MENTAL DEVELOPMENT OF CHILDREN WHO 
HAVE SUFFERED FROM PERINATAL HYPOXIC DAMAGE OF CENTRAL NERVOUS 
SYSTEM 
I.V.Тarasova, SM.Kasyan, M.L. Radchenco, Akinjolire Oluwagbenga John 
Sumy State University, Department of Pediatrics with Medical Genetics 
The problem of children adaptation who suffered from perinatal hypoxic damage (PHD) of 
the central nervous system (CNS) is very important. The brain damage on the early stages of ontogeny 
violates deterministic evolutionary scenario of pre-, intra-and postnatal adaptation, slows ripening of 
parameters of functional CNS, which increase the likelihood of developing of secondary cerebral 
defects. The effects of PHD of CNS reflect not only the severity of injuries, but the effectivenes of 


English

https://essuir.sumdu.edu.ua/bitstream/123456789/41250/3/%d0%a2arasova_I.V..pdf

Content of cobalt in biological fluidsoffull-term newborns as the predictor of perinatal hypoxic damage of CNS

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