FUJIE, H

ISHIDA, K

LEE, JD

MITSUKE, Y

MORISHITA, T

NAKANO, A

SAKATA, J

SARAZAWA, K

SATOU, T

UZUI, H

University of Fukui Repository

JOURNAL OF CARDIAC FAILURE 
14(7), S161-S161, Supplement: Suppl. 1, SEP 2008 Title: 
 
Elevated Levels Of Serum Interleukin-12p40 May Reflect Disease Severity Of P 
atients With Chronic Congestive Heart Failure  
 
Mitsuke Y, Uzui H, Nakano A, Sakata J, Sarazawa K, Ishida K, Satou T, Fujie H, 
Morishita T, Lee JD.    
 
Division of Cardiology, University of Fukui Hospital, Fukui, Japan  
 
Interleukin(IL)-12p40 is a linchpin immunoregulatory cytokine to promote 
the development of a Th1 type immune response. To examine whether serum levels of 
IL-12p40 are increased in patients with CHF and to determine whether a correlation 
exists between disease severity and serum levels of IL-12p40 of patients with chronic 
CHF, we assessed the serum levels of IL-12p40 in 56 patients with CHF (LVEF&lt;40%, 
NYHA II-III) and age-matched 20 healthy volunteers using enzyme-linked 
immunosorbent assay. Results: The serum levels of IL-12p40 were significantly higher 
in CHF patients than in healthy volunteer (81.3&plusmn8.1 vs 25.7 &plusmn2.9 ng/ml, 
p&lt;0.01). The serum levels of IL-12p40 showed significant positive correlations with 
NYHA functional class, serum levels of tumor necrotic factor-alpha, IL-1beta, IL-6, and 
BNP in patients with CHF. Cardiac death and rehospitalization due to worsening heart 
failure occurred more frequently in a high serum levels of IL-12p40 group 
(&gt;54.0ng/ml,n=28) of CHF patients than in a low serum levels of IL-12p40 group 
(&lt;54.0ng/ml,n=28) for a mean follow-up period of 27.5 months. Furthermore, serially 
measured serum levels of IL-12p40 decreased significantly along with improvement in 
NYHA class under medication with carvedilol in 12 patients. Conclusions: Our data 
showed that the circulating IL-12p40 levels may relate to severity of patients with heart 
failure syndrome. 


Elevated Levels Of Serum Interleukin-12p40 May Reflect Disease Severity Of P atients With Chronic Congestive Heart Failure

Elevated Levels Of Serum Interleukin-12p40 May Reflect Disease Severity Of P atients With Chronic Congestive Heart Failure

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