Although animal studies suggest that centrally active angiotensin-converting enzyme （ACE） inhibitors
may protect against dementia beyond HTN control, the mechanism（s） underlying these improvements in cognitive
function remains unclear. We measured the brain peptide levels in rat treated with captopril（ 50 mg/kg） for 3 weeks
by using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry （SELDI TOF-MS）. Two
protein chip arrays were used for peptide profi ling： one with a strong anion- exchanger and the other with a weak
cation-exchanger.
Comparing with control group, 15 mass peaks were considered specifi c to experimental animals, and 6 peaks were
signifi cantly up-regulated and 5 down-regulated
