Toxicokinetics of solid particles in chronic studies using diesel soot, carbon black, toner, titanium dioxide and quartz

Abstract

During the past five years, various chronic inhalation studies with solid particles have been performed at the Fraunhofer-Institute of Toxicology and Aerosol Research (ITA) and at the Inhalation Toxicology Research Institute in Albuquerque, NM, USA (ITRI). The inhaled materials include titanium dioxide, carbon black, soot from diesel exhaust, toner for copy machines, and quartz. The objectives of this paper are presentation of retention data from three studies in a comparative manner, illustration of the relationship between lung burden and macrophage-mediated clearance, and presentation of a model by which an appropriate aerosol concentration can be selected for chronic studies