Background Diclofenac sodium is an NSAID that is often used to treat
musculoskeletal pain, such as rheumatoid arthritis, osteoarthritis, ankylosing
spondylitis, spondiloartritis, and gouty arthritis. The side effects were reported in
30% of patients in the form of impaired renal function. This drug is known to
cause oliguria caused by a decrease in renal blood flow and glomerular filtration
rate of the kidneys.
Aim To know the effect of diclofenac sodium 1,4 mg/kgBW and 2,8 mg/kgBW oral
administration toward serum levels of urea of wistar rats.
Methods Experimental study Post Test Only Control Group Design. The samples
were 21 male wistar rats, randomized in to 3 groups. Group I was not given
diclofenac sodium (control), Group II was given diclofenac sodium 0,6 mg and
Group III was given diclofenac sodium 1,2 mg. Administration through gastric
instillation thrice a day for 14 days. Blood samples were collected at the 15th day
through retroorbital vascular and the urea levels were measured using standard
methods. Data analysis used One-Way ANOVA Test and Post-Hock Test.
Statistical analysis was conducted by computer program.
Results There was no significant increase in the average value of the urea levels
from the control group toward Group II and Group III. One-Way ANOVA test
showed that there was no significant difference (p=0.819) among all of groups.
Post-Hock test also showed that there were no significant differences in the
control group toward Group II (p=0.554), control group toward Group III
(p=0.649), and Group II toward Group III (p=0,889).
Conclusion Administration of diclofenac sodium 1.4 mg/kgBW and 2.8 mg/kgBW
for 14 days did not cause a significant increase in urea levels.
Key Words: Diclofenac sodium, urea levels
