Infrared breath analysis is used in diagnostics of respiratory diseases, pulmonary function testing, and for metabolic studies. With selective and highly sensitive instruments exhaled trace gas concentrations can be related to specific diseases.For many applications also a time resolution below 0.1s is needed. Frequently, performance is limited by the IR source. New developments offer solutions even for compact instruments. Different setups employing quantum cascade lasers (QCL), VCSELs, and a new optically pumped IR emitter are compared focusing on CO2 measurements as an example