The oral cavity is a very widely distributed ecosystem in which several hundred microbial species normally cohabit harmoniously. Under special conditions some microorganisms with potential are promoted, leading to inflammation & infection by induced de-mineralization of dental enamel that normally constitutes an impermeable barrier that protects the underlying dentin and the connective tissue situated in the center of the tooth & dental pulp such as pulpitis, dental caries, and periodontal infection. In inflammation of the dental pulpitis the immunity response against oral infection leads to infection and results in a high level of morbidity and economic burden to society
