Study Mechanism Of Action Of Krishnavajrabhraka Bhasma In Asthma

Abstract

Objective: To evaluate the mechanism of action of Krishnavajrabhraka Bhasma(KVB) in chronic asthma.
Methodology: 30 animals divided into 5 groups: 1)vehicle(water) 2)vehicle(honey) 3)Low dose KVB 4)High dose KVB 5)Standard drug.
Expt I:- Mast cell stabilization-
On day 1, animals were sensitized with egg albumin. Treatment started from day 22 in two ways: a)Single dose b)14days. Egg albumin challenge was given at the end of the treatment. Rats were sacrificed, mesentery collected & observed for mast cell degranulation. 
Expt II:- Anti-inflammatory action-
Croton oil was injected in the back in all rats to make a pouch. After 7 days of drug treatment, animals were sacrificed, pouch removed & weighed. Exudate was measured.
Results:
Expt.I – KVB was found to have mast cell stabilizing action in both experiments. High dose of KVB was equally effective as sodium-cromoglycate.
Expt.II – High dose of KVB showed significant reduction of inflammation comparable to diclofenac.
Conclusion: KVB has mast cell stabilizing & anti-inflammatory activity