Cukalovic, Ana

De Blieck, Ann

Heugebaert, Thomas

Heynderickx, Geraldine

Marin, Guy

Monbaliu, Jean-Christophe

Roman, Bart

Stevens, Christian

Thybaut, Joris

English

Ghent University Academic Bibliography

APPLICATION OF MICROREACTOR TECHNOLOGY FOR CYANOHYDRIN PRODUCTION: EXTENDING THE SCOPE TOWARDS RENEWABLE RESOURCES Ana Cukalovic, J.-C.M.R. Monbaliu, T.S.A. Heugebaert, B.I. Roman, A. De Blieck, J.W. Thybaut, G.B. Marin, C.V. Stevens* Ghent University, Dpt. of Sustainable Organic Chemistry and Technology and Laboratory for Chemical Technology, Ghent, Belgium ana.cukalovic@ugent.be  Addition of hydrogen cyanide to functional groups is not widely developed industrially because of safety issues regarding the handling of HCN. In situ production of HCN from cyanide salts and a H+ source definitely presents a safer route for handling such processes. Microreactor technology allows a variety of reactions including cyanohydrin production on a micro and milli-scale with an increased efficiency and safety. R R'OR R'HO CNKCNCH3COOHR, R'=H, CH3, CH2OH, (CHOH)nCH2OHH+ or OH-H2OR R'HO COOH  Acetone cyanohydrin production is inevitably connected with a certain safety risk related to the management of HCN in the gaseous or the liquid state. While safely handling the HCN in the closed system, we have achieved a 99% conversion to a >98% pure product by simple modification of the reaction conditions, at relatively low temperature and with a high throughput.  The Kiliani reaction – leading to the extension of the carbohydrate chain by the addition of HCN to a carbonyl group – is a well-known reaction and a convenient synthetic tool opening the way towards α-hydroxycarboxylic acids, important building blocks in organic chemistry. Due to the unfavourable equilibrium, it is difficult to obtain high conversions in a reasonable reaction time under batch conditions. Under microreactor conditions it is possible to obtain a significant increase in reaction efficiency and conversions of up to 99% to the nitrile and/or the corresponding acid, i.e., the product of the in situ nitrile hydrolysis. This good result is, however, limited to the lower chain carbohydrates, as with the increase of the number of C atoms in the carbohydrate skeleton the reaction is adversely affected by a number of practical difficulties, such as hemiacetal formation and the solubility of the substrates. Inlet 2Inlet 1µ-mixing unitsubstrate+ CH3COOHKCN Outlet 2Outlet 1HCNg capture and neutralisation(KOH, Na2S2O3)RTU  *The presenting author acknowledges financial support from the Long Term Structural Methusalem Funding by the Flemish Government. 

Application of microreactor technology for cyanohydrin production : extending the scope towards renewable resources

https://biblio.ugent.be/publication/1886889/file/1887865.pdf

Application of microreactor technology for cyanohydrin production : extending the scope towards renewable resources

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Ghent University Academic Bibliography