Skirtach, Andre

Ghent University Academic Bibliography

Open AccessEditorialBiochips & Tissue ChipsSkirtach., Biochip Tissue Chip 2012, 2:1http://dx.doi.org/10.4172/2153-0777.1000e109Volume 2 • Issue 1 • 1000e109J Biochip Tissue ChipISSN: 2153-0777 JBTC, an open access journalResearch in the area of bio-interfaces is rapidly growing due to its unique position at the junction of material science and biology, while on the other hand due to its applications in biomedicine, biology and drug delivery [1,2]. Designing advanced coatings, tissue engineering, implants or simply substrates for cell culture handling requires exten-sive knowledge of the interaction of bio-molecules, their mechanical stability and surface functionalization. Nanotechnology, in general, and a closely related area of layer-by-layer [3] films [4-6] are well posi-tioned for taking on challenges of interfacing material science and bio-medicine. Some of the most significant advantages of the layer-by-layer technique are its versatility and multifunctionality. Recently developed method of controlling the interaction of the constituent layers, for example hyaluronic acid and poly-l-lysine, al-lowed to build thick, bio-compatible films [5]. A very big advantage of such films is their reservoir-like capacity to enclose bio-molecules as well as controllable diffusion of biomolecules in such films. Modifica-tion of such films with silver nanoparticles for SERS detection has been recently shown [6], while we have recently demonstrated functionaliza-tion of such films by gold nanoparticles [7]. Such a modification allows for selective surface modification of these films by remote laser irradia-tion [7], which can also serve the purpose of controlling mechanical properties of such films. Mechanical properties, which are investigate by the so-called colloidal probe approach [8], are very important pa-rameter of substrates and coatings since they alone can differentiate growth and proliferation of cells and tissue cells [9]. Peculiarly, even addition of gold nanoparticles without remote activation can be used to control films’ mechanical properties. Films with higher stiffness are produced by increasing the concentration of gold nanoparticles on their surface. In fact, the E-modulus of such films was observed to in-crease from less than 300 MPa to more than 900 MPa (over three fold increase) by addition of 900 µl of gold nanoparticle solution [10]. On the other hand, this increased stiffness of films can be used for control-ling protrusion of embedded particles. Since such bio-films represent some of the most biocompatible coatings they are very attractive can-didate for processing other particles and drug delivery carriers. For ex-ample, they can be used for selective masking of particles and capsules adsorbed onto their surface. And if the nanoparticles alter the stiffness of the films, then it is expected that particles or capsules adsorbed to their surface would protrude differently depending on the concentra-tion of nanoparticles. Such an approach represents a facile method to control the patchiness of particles in a completely biocompatible proc-ess [10]. Alternatively, mechanical properties control of films can be achieved by polyanions mixture [11], while their modification can be performed with microcapsules [12]. The ultimate goals of research in this area include designing novel bio-interfaces and improving cells growth. As such, implementation of such goals would open new ways of designing optimized coatings for tissue engineering. Further functionalization of such surfaces with bio-molecules as well as with nanoparticles for remote activation are expected to open novel routes for controlling cell adhesion and film based drug delivery [13,14]. It is expected also that such films and bio-interfaces can be adapted for and incorporated into biochips, thus ena-bling additional venues for surface functionalization and modification. References1. Skirtach AG, Kreft O (2009) Nanotechnology in drug delivery, Springer, Berlin, Germany. 2. Delcea M, Möhwald H, Skirtach AG (2011) Stimuli-responsive LbL capsules and nanoshells for drug delivery. Adv Drug  Deliv Rev 63: 730-747. 3. Decher G, Hong JD, Schmitt J (1992) Build-up of ultrathin multilayer films by self-assembly process. Thin Solid Films 210: 831-835. 4. Cho J, Quinn JF, Caruso F (2004) Fabrication of polyelectrolyte multilayer films comprising nanoblended layers 126: 2270-2271. 5. Picart C (2008) Polyelectrolyte multilayer films: from physico-chemical proper-ties to the control of cellular processes. Curr Med Chem 15: 685-697. 6. Abalde-Cela S, Ho S, Rodriguez-Gonzalez B, Correa-Duarte MA, Alvarez-Pue-bla RA, et al. (2009) Loading of exponentially grown LBL films with silver na-noparticles and their application to generalized SERS detection. Angew Chem Int Ed 48: 5326-5329.7. Skirtach AG, Volodkin DV, Möhwald (2010) Bio-interfaces - interaction of PLL/HA thick films with nanoparticles and microcapsules. Chem Phys Chem 11: 822-829. 8. Fery A, Weinkamer R (2007) Mechanical properties of micro - and nanocap-sules: single-capsule measurement. Polymer 48: 7221-7235. 9. Discher DE, Janmey P, Wang YL (2005) Tissue cells feel and respond to the stiffness of their substrate. Science 310: 1139-1143. 10. Kohler D, Madaboosi N, Delcea M, Schmidt S, De Geest BG, et al. (2012) Patchiness of embedded particles and film stiffness control through concentra-tion of gold nanoparticles. Adv Mater 24: 1095-1100. 11. Trenkenschuh K, Erath J, Kuznetsov V, Gensel J, Boulmedias F, et al. (2011) Tuning of the elastic modulus of polyelectrolyte multilayer films built up from polyanions mixture. Macromol 44: 8954-8961.12. Volodkin DV, Delcea M, Möhwald H, Skirtach AG (2009) Remote near-IR light activation of a hyaluronic acid/poly(L-lysine) multilayered films and film en-trappedmicrocapsules. ACS Appl Mater Interfaces 1: 1705-1710.13. Jewell CM, Zhang JT, Fredin NJ, Lynn DM (2005) Multilayered polyelectrolyte films promote the direct and localized delivery of DNA to cells. J Control Re-lease 106: 214-223. 14. Volodkin DV, Madaboosi N, Blacklock J, Skirtach AG, Möhwald H (2009) Sur-face-supported multilayers decorated with bio-active material aimed at light-triggered drug delivery. Langmuir 25: 14037-14043. *Corresponding author: Andre G. Skirtach, Department of Interfaces, Max-Planck Institute of Colloids and Interfaces, Am Muehlenberg 1, Research Campus Golm, Potsdam D-14476, Germany, E-mail: Andre.Skirtach@mpikg.mpg.deReceived February 29, 2012; Accepted March 02, 2012; Published March 05, 2012Citation: Skirtach AG (2012) Bio-interfaces: At the Junction of Material Science and Biology. J Biochip Tissue chip 2:e109. doi: 10.4172/2153-0777.1000e109Copyright: © 2012 Skirtach AG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Bio-interfaces: At the Junction of Material Science and BiologyAndre G. Skirtach1,2 1Department of Molecular Biotechnology, Ghent University, Ghent 9000 Belgium 2Max-Planck Institute of Colloids and Interfaces, Research Campus Golm, Golm 14476, Germany`

Bio-interfaces: at the junction of material science and biology

https://biblio.ugent.be/publication/4080597/file/4080598

Bio-interfaces: at the junction of material science and biology

Abstract

Similar works

Full text

Available Versions

Ghent University Academic Bibliography