In order to inventory anopheline species and assess entomological parameters directly involved in the transmission of malaria to humans, an entomological study based on nocturnal captures of adult mosquitoes on human bait was carried out during the dry and rainy season of 2022 at four sites in the town of Mokolo, Far North Cameroon. Mosquitoes were captured on human bait using the method developed by Le Goff et al. (1992). A total of 2835 adult anopheles were captured at the four sites in the town of Mokolo. Anopheles gambiae s.s ranked first in proportion (1705/2835), i.e. 60.14%, followed by Anopheles arabiensis (882/2835), i.e. 31.11%, Anopheles funestus (248/2835), i.e. 8.74%. The anopheles aggressiveness rate is 13.32 p/h/year. Of the 1705 female of Anopheles gambiae ss ovaries dissected, 1258 showed parous ovaries, giving an average share rate of TP=73.78%. Which means that the town of Mokolo is an epidemiologically dangerous zone. The average daily vectorial capacity is 25.34 days. This means that Anopheles gambiae ss is potentially responsible for more than 25 new infections per day. The average annual malaria stability index in Mokolo is Ist =9. This classifies Mokolo as an area of stable transmission during the study period