A lack of knowledge on the fatigue resistance of self-compacting concrete (SCC) structures has led to the research presented in this paper. Several reinforced concrete beams were subjected to both static and cyclic four-point bending tests in order to determine the failure mechanism, the static ultimate load, the fatigue performance, the deformation, and crack width evolution. For comparison purpose, different mixtures were considered, including a vibrated concrete (VC) type and two SCCs (one with similar strength and one with equal w/c ratio, compared to VC). The mutual relationship is strongly depending on the stress level caused by the repeated loading