Anssens, Sarah

Coppens, Marc

De Hert, Stefan

Deschepper, Ellen

Wouters, Patrick

English

Ghent University Academic Bibliography

Determination of the median effective dose of chloroprocaine in labour: preliminary resultsBackground and Goal of Study: Chloroprocaine is an old local anaesthetic with renewed interest for its beneficial pharmacodynamic/kinetic profile, which appears particularly suitable for intrathecal analgesia in labour1. However, the commonly used dosages are arbitrarily chosen and may be excessive. The primary goal of this study was to determine the median ef fective dose (ED50) of Chloroprocaine when given intrathecally as part of a combined spinal-epi-dural analgesia regimen for labour using an up-and-down method2. Materials and Methods: In this prospective trial 18 parturients, with a preg-nancy duration of 36 to 41 weeks, requesting analgesia, were given a com-bined spinal-epidural analgesia and received a predetermined dose of chloro-procaine 1% intrathecally, according to an up-down sequential allocation. The initial dose of chloroprocaine was chosen to be 20mg and the testing interval was set at 2mg. Analgesic ef fectiveness was accepted if the visual analog pain score decreased to 10mm or less on a 100mm scale within 15 minutes. Af ter the study period parturients were of fered a conventional patient controlled epidural analgesia protocol with levobupivacaine and sufentanil.Results and Discussion: Using the Dixon and Mood method, the median ef fective dose of intrathecal chloroprocaine in the spinal component of a CSE for labour was calculated to be 15 mg (95% CI:11.7-18.3 mg). Conclusion(s): To our knowledge, this is the first study to calculate a median ef fective dose for spinal chloroprocaine for labour analgesia. Further inclu-sion of patients will allow to refine the confidence intervals. References: 1.  Columb, O.M., et al. Determination of the minimum local analgesic concentration of epidural chloroprocaine hydrochloride in labor. International journal of obstetic anesthesia, 1997. 6: 39-42. 2.  Pace N.,Stylianu M. Advances in and limitations of up-and-down methodology. Anesthesiology 2007.This item is the archived peer-reviewed author-versionEuropean Journal Of Anaesthesiology (2015), Volume 32, e-supplement 53, p. 113Anssens, Sarah; De Schepper, E.; Wouters, Patrick; De Hert, Stefan

Determination of the median effective dose of chloroprocaine in labour: preliminary results

https://biblio.ugent.be/publication/7007312/file/7007769

Determination of the median effective dose of chloroprocaine in labour: preliminary results

Abstract

Similar works

Full text

Available Versions

Ghent University Academic Bibliography