Present day knowledge concerning the liver is derived from many sources and the accumulation of many methods of investigation. Sugar, which is needed by the body for energy, is stored in the liver as glycogen. Claude Bernard (26), an eminent physiologist, was the first to suspect that carbohydrates were stored in the liver. Faulty glycogen synthesis and hydrolysis results in one of our most widespread diseases, diabetes. Thus, many biochemists and physiologists have tried to find the mechanism of the process, and the primary and secondary facts which affect glycogenesis and glycogenolysis. Although the chemical secretions and hormones of such organs as the pancreas, the pituitaries, and the adrenals do exert an influence, recent work by such men as Soskin, (24) and Simpson and Macleod (23), indicates that the principal action lies in the liver itself. Nevertheless, the importance of the internal glands cannot be overlooked
