Batens, Katja

De Letter, Miet

Aerts, Annelies

Raedt, Robrecht

Duyck, Wouter

Van Roost, Dirk

Santens, Patrick

English

Ghent University Academic Bibliography

 Neuroanatomical imaging and behavioural language testing give no insight in   • Neurophysiological language processes. • Neuroplasticity changes.  Event related potentials (ERP)  • Timing and amplitude of neural activity (Pettigrew et al., 2005). • Seem to be more sensitive for detecting deviations than behavioural testing (Elting et al., 2008).   Aim • A description of the behavioural and electrophysiological evolution of the phonological input processes of a single subject during the first year after stroke, in timeframes with and without therapy. MMN P300 N400 PoA Voicing MoA PoA Voicing MoA RW PW Intensive 1 T1<>T2 ↑ ↓ ↑ ↑ ↑ Conventional  T2<>T3 ↑ ↑ ↑ ↑ ↓ Intensive 2 T3<>T4 ↓ ↑ ↓ ↓ ↑ Follow up  no therapy T4<>T5 ↓ ↓ ↓ ↓ ↓ ↓  Patient  • A 46-year-old right-handed male patient  • Ischemic cerebrovascular accident of  the left middle cerebral artery  • No neurological antecedents   Linguistic tests and therapy                    • Elting, J. W., Maurits, N., van Weerden, T., Spikman, J., De Keyser, J., & van der Naalt, J. (2008). P300 analysis techniques in cognitive impairment after brain injury: Comparison with neuropsychological and imaging data. Brain Injury, 22(11), 870-881.  • Pettigrew, C. M., Murdoch, B. E., Kei, J., Ponton, C. W., Alku, P., & Chenery, H. J. (2005). The mismatch negativity (MMN) response to complex tones and spoken words in individuals with aphasia. Aphasiology, 19(2), 131-163.   Clinical use of event-related potentials in diagnostic and therapeutic evaluation of phonological input processes:  A one year follow-up case study  Katja Batens a,b, Miet De Letter a,c, Annelies Aerts d, Robrecht Raedt a,d, Wouter Duyck e, Dirk Van Roost f, Patrick Santens a,d  (a) Department of Neurology, Ghent University Hospital; (b) Department of Rehabilitation Sciences and Physiotherapy, Ghent University Hospital; (c) Department of Speech, Language and Hearing Sciences, Ghent University; (d) Department of Internal Medicine, Ghent University; (e) Department of Experimental Psychology, Ghent University; (f) Department of Neurosurgery, Ghent University Hospital. References Behavioural testing Neurophysiological testing Auditory discrimination Phoneme discrimination PALPA 1 & 2 6 oddball paradigm  •  Unattended (MMN) and attended (P300)  • based on 3 distinctive features: ‐ Place of articulation (PoA) ‐ Voicing ‐ Manner of articulation (MoA) Auditory lexical decision Word recognition  PALPA 5 1 oddball paradigm (MMN)  Benefits of neurophysiological examination:  • Higher sensitivity than behavioural testing, obviating ceiling effects. • Identification of underlying neuronal activation patterns of certain behavioural improvements.  • The alterations of the N400 are very sensitive for mapping the evolution of therapy progression.  Challenges:  • Interpretation of fluctuating P300 in recovery of aphasia Discussion & conclusion  -5,2 -3,9 -2,6 -1,3 0 1,3 2,6 3,9 5,2 6,5PALPA 1 PALPA 2 PALPA 5 real words PALPA 5 pseudowordsIntensive 2 T3<>T4 Intensive 1 T1<>T2 Conventional  T2<>T3 Follow up  no therapy T4<>T5 T1 Intensive therapy T2 Conventional therapy T3 Intensive therapy T4 T5 1w 4 w   5 w 12 w   13 w 16 w      1 y  Behavioural evolution  Size effects of behavioural results             Neurophysiological evolution Amplitude changes of neurophysiological results              ↑ Significant amplitude increase ↓ Significant amplitude decrease Results  Introduction  R L Method  

Clinical use of event-related potentials in diagnostic and therapeutic evaluation of phonological input processes: a one year follow-up case study

https://biblio.ugent.be/publication/4342839/file/4342845

Clinical use of event-related potentials in diagnostic and therapeutic evaluation of phonological input processes: a one year follow-up case study

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Ghent University Academic Bibliography