Andersen, Stephen

Arends, Jan

Candry, Pieter

Denis, Kyrina

Nopens, Ingmar

Rabaey, Korneel

Van Daele, Timothy

English

Ghent University Academic Bibliography

LabMETLaboratory of Microbial Ecology and Technology - Faculty of Bioscience Engineering – Ghent universityCoupure Links 653, 9000 Ghent, Belgiumwww.labmet.ugent.beOptimisation of fermentation and extraction for productionof Medium Chain Fatty Acids (MCFA)MCFA as chemical building blocksP. Candry1, S.J. Andersen1, K. Denis1,2, T. Van Daele2, J.B.A. Arends1, I. Nopens2, K. Rabaey11Laboratory of Microbial Ecology & Technology, Ghent University2 BIOMATH, Ghent UniversityPrimaryFermentationChain ElongationExtraction & RecoveryCarbon FlowProcessInteractionsVFA, EtOHMCFAModelling of MCFA-productionVarying substrates & concentrationsBio-refineries……sustainably produce materials, fuels and energy…reduce fossil fuel dependency…recover nutrients & carbon present in (agro)-industrial wastestreamsChain Elongation:Condensation of Volatile Fatty Acids (VFA, e.g. Acetic acid) with EtOH to Medium, Chain Fatty Acids (MCFA)Extraction & Recovery: Separation of the target product from the broth to recover the MCFAMCFA…… include Caproic acid (C6), Caprylic acid (C8), Capric acid (C10) & Lauric acid (C12)… can be used as antimicrobial agents in feedstocks… are precursors for solvents, fuels and other chemicalsABCDEFGH1 2 3 4 5 6 7 8 9 10 11 12Monod-kineticsKinetic mass,,balance modelParameter estimation: Y, KI, etc.Application to real streams96-well plate kinetic experimentsPure Chain Elongating culture: C. kluyveriUndefined Community Capable of Chain ElongationWaste streamSubstratecharacterizationProduct targetingOptimal recovery of carbon in waste stream00,20,40,60,810 5 10 15 20 25 30 35 40OD (-)Time (h)St.Dev. M. elsdenii - PYG-medium Model FitµMCFA-productionmodelCombining the knowledge of what is in a wastestream with what is possible allows targetingthe optimal product for carbon-recoveryDifferent µAcknowledgementsResearch funded by Ghent University Special Research Fund (BOF) & ElectrotalkGrowth rate µSubstrate ConcentrationKsµ𝑚𝑎𝑥2µ𝑚𝑎𝑥European Research Council Starter Grant ELECTROTALK

Optimisation of fermentation and extraction for production of medium chain fatty acids (MCFA)

https://biblio.ugent.be/publication/7229194/file/7229203.pdf

Optimisation of fermentation and extraction for production of medium chain fatty acids (MCFA)

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Ghent University Academic Bibliography