This report describes a clinical case of chronic monocytic ehrlichiosis in a dog that originated from Spain. The patient was presented with chronic unilateral epistaxis. Hematologic and biochemical abnormalities namely anemia, thrombocytopenia, neutropenia, lymphocytosis, hyperproteinemia, hypoalbuminemia and hypergammaglobulinemia together with the anamnesis, suggested an infection with Ehrlichia canis. Although gammopathy caused by ehrlichiosis is usually polyclonal, serum protein electrophoresis revealed a monoclonal gammopathy. E.canis titers were strongly positive. The dog was treated with doxycycline for a period of eight weeks, which led to resolution of the clinical signs and laboratory abnormalities, except for persistent hyperproteinemia. Proteinuria was recognized one year later. This was probably due to glomerular damage as a result of chronic ehrlichiosis. Combination therapy with doxycycline, a low protein diet, an ACE-inhibitor and acetylsalicylic acid lead to a significant reduction in the magnitude of proteinuria
