Calders, Patrick

De Paepe, Anne

De Schepper, Joris

Malfait, Fransiska

Rombaut, Lies

Verschelde, Sabine

English

Ghent University Academic Bibliography

IMPACT OF EHLERS DANLOS SYNDROM - HYPERMOBILE TYPE  ON LOWER LIMB FUNCTION INTRODUCTION The consequences of  the  hypermobility type of Ehlers-Danlos Syndrome (EDS-HT)  on various joints all over the body, are known.  According to  Maeland et al. , 98% of the patients report musculoskeletal symptoms. However, specific details on lower extremity in general, and  foot and ankle in specific, are hardly inventoried.  METHODOLOGY Subjects: 23 female EDS-HT patients (age : 44.3±12.3; Beighton:6.3±1.9)  and 23, sex and age matched, control subjects (age : 44.7±12.3, Beighton: 2.8±1.8 ) were included.  Materials: • The Foot Function Index (FFI) was used to assess the presence of foot  disorders in terms of pain, disability and activity restriction. • The Lower Extremity Function Scale (LEFS) was used to evaluate functional impairment of lower extremity in EDS-HT patients. • The ‘Foot Health Status Questionnaire’ (FHSQ) was used to evaluate foot health related quality of life.      AIM OF THIS STUDY   • The objective of this explorative study was to evaluate foot related problems and their impact on  lower limb function in patients with EDS-HT. • Different specific domains were covered:  • foot pain  • foot function  • physical activity restriction of the lower limb.  RESULTS Concerning the FFI, patients with EDS-HT scored significantly higher  for the domain of ‘pain’ and for ‘physical disability’, indicating a significant reduced  foot function for the patient group due to foot disorders compared to the healthy control group. (Table 1) Total LEFS scores, measuring  the functional impairment of a patient with a disorder of one or both lower extremities, were significant lower in the EDS-HT group compared to the control indicating severe impact on lower extremity function. Table 1 demonstrates the results in terms of percentage.  Regarding the FHSQ, EDS-HT subjects  vs. controls scored significantly higher for foot pain (theoretical construct : type, severity and duration), for foot function (feet impact on physical function), for general foot health  (self perception of feet – body image) and significantly lower for shoe information (lifestyle/footwear).  (Table 2)  Campus Kantienberg Voetweg 66 9000 Gent joris.deschepper@arteveldehs.be Joris.deschepper@ugent.be www.arteveldehs.be  De Schepper J. (1,2), Verschelde S. (1), Malfait F. (3), De Paepe A. (3), Calders P. (2), Rombaut L. (2,1)   1, Department of Podiatry, Artevelde University College, Ghent, Belgium 2, Department of Rehabilitation Sciences and Physiotherapy, Ghent University – Artevelde University College, Ghent, Belgium 3, Center for Medical Genetics, Ghent University, Ghent, Belgium Despite the limitations of the study, EDS-HT has proven to have  a large disabling impact on foot function as  well as on the entire lower limb segment.  The need for adequate screening and appropriate interventions clearly arises.   CONCLUSION Tabel 1 : results in terms of percentage CG vs. EDS-HT Tabel 2: between group detail on FHSQ 

Impact of Ehlers Danlos Syndrom-Hypermobile Type on lower limb function

https://biblio.ugent.be/publication/2999483/file/2999988.pdf

Impact of Ehlers Danlos Syndrom-Hypermobile Type on lower limb function

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Ghent University Academic Bibliography