Aakhus, Svend

Aulie, Hanne

Estensen, Mette-Elise

Flato, Berit

Lilleby, Vibke

Molberg, Oyvind

Segers, Patrick

Selvaag, Anne Marit

English

Ghent University Academic Bibliography

Increased Arterial Stiffness in Juvenile Idiopathic Arthritis (JIA) Patients Compared with Matched Controls - a pilot study  Hanne Aulie MD¹, Mette-Elise Estensen MD², Anne M Selvaag MD PhD¹, Patrick Segers MS³,  Øyvind Molberg MD PhD¹, Vibke Lilleby MD Phd¹, Svend Aakhus MD PhD², Berit Flatø MD PhD¹ 1. Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.  2. Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway 3. IBiTech-bioMMeda, Ghent University, Ghent, Belgium   Purpose Systemic arterial properties in adult patients with JIA are not well described. The aim of this study was to evaluate arterial properties in young adults with JIA compared with age- and sex-matched controls.  Methods Nineteen patients (37.7±3.4 years) were randomly selected from a cohort of 88 JIA-patients who were followed from their first referral to Oslo University Hospital in 1980 -85 and had  active disease more than 14 years after disease onset. Of the 19 patients, 2 had systemic JIA, 3 polyarticular RF negative, 1 polyarticular RF positive, 3 oligoarticular persistent, 5 oligoarticular extended, 3 enthesitis related, 1 psoriasis arthritis and 1 had undifferentiated arthritis. The patients were investigated after a mean disease duration of 29.2 ±1.3 years and compared with 19 age- and sex-matched controls. Aortic root pressure and flow data were obtained no invasively by brachial arterial blood pressure, calibrated carotid arterial pulse trace and aortic annular Doppler flow recordings. The systemic arterial properties were described by the total arterial compliance (C), characteristic aortic impedance (Z0), and peripheral arterial resistance (R) obtained from estimation of 3-element windkessel model (WK) parameters (C, Z0, R), by Fourier analyses of central aortic pressure and flow data (Z0),   Results (Table) The proximal aortic stiffness, evaluated by Z0, was significantly higher, in the JIA-patients compared to the healthy controls (p=0.016). The patients also had lower total arterial compliance (C) (p=0.022), but the arterial resistance (R) was not different. The heart rate was higher in the patients than in the controls (p=0,043), but the blood pressure did not differ between the groups (p=0.443, p=0.535).  Conclusion In spite of similar blood pressure, JIA patients have stiffer proximal aorta, and lower total arterial compliance than matched controls. This indicates that JIA-patients with long term active disease experience significant alteration of arterial function.   Table   Variables JIA-patients Mean ± SD Controls Mean ± SD P-value (unpaired t-test) BMI 25.7 ± 4.9 25.3 ± 4.0 0.785 Systolic blood pressure (mmHg) 117 ±15 114 ±11 0.443 Diastolic blood pressure (mmHg) 69 ± 9 68 ± 9 0.535 Heart rate (beats/s) 67 ± 11 60 ± 8 0.043 Cardiac output( l min -1) 5.3 ± 1.1 5.3 ± 0.9 0.982 R (mmHg/(ml/s)) 1.04 ± 0.21 1.00 ± 0.23 0.564 Z0 Windkessel Model (WK)  (10^-3 mmHg/ml/s))  77 ± 25 58 ± 20 0.016 C Pulse pressure method (PPM) (ml/mmHg) 1.21 ± 0.24 1.44 ± 0.34 0.022  

Increased Arterial Stiffness in Juvenile Idiopathic Arthritis (JIA) patients compared with matched controls - a pilot study

https://biblio.ugent.be/publication/3180778/file/3231072

Increased Arterial Stiffness in Juvenile Idiopathic Arthritis (JIA) patients compared with matched controls - a pilot study

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