Type1 and type2 diabetus mellitus patients; Exocrineinvestigation of the frequency of pancreas failure and various clinic and investigation of the relationship with laboratory parameters

Abstract

Introduction: Pancreatic enzyme deficiency (PEI) is a common clinical condition in patients with Diabetes Mellitus. The aim of our thesis study is to determine the frequency of pancreatic enzyme insufficiency in patients with Type 1 or Type 2 DM in Necmettin Erbakan University Meram Faculty of Medicine, Department of Internal Medicine, Endocrinology and Metabolism Diseases Department and service, and to retrospectively examine the clinical and laboratory tests of these patients and evaluate the difference to evaluate relationships. Methods: Fecal samples were obtained from 165 patients with Type 1 or Type 2 DM who were followed up in Necmettin Erbakan University Meram Faculty of Medicine, Department of Internal Diseases, Endocrinology and Metabolic Diseases Outpatient Clinic and service. The fecal samples taken were kept at -80 degrees until FE-1 biochemistry study kits were obtained. Fecal elastase 1 (FE1) level was measured using enzyme-linked-immune assay (ELISA) kits for the presence of PEI in fecal samples. Fecal elastase levels of 200 μg/g were classified as normal exocrine function, 100-200 μg/g as mild to moderate exocrine pancreatic insufficiency (PEI), and <100 μg/g as severe PEY. The patients were divided into 3 main groups as type 2 DM using insulin, type 2 DM only using OAD, and type 1 DM. In our study, the clinical and laboratory tests between these 3 groups were retrospectively analyzed and the relationship between them was evaluated. A questionnaire was administered to the patients regarding the diagnosis and symptoms of PEY. According to the results of the questionnaire, they were evaluated as patients with mild, moderate and severe PEI symptoms and who were not considered to have PEI. In conclusion: Of 165 patients with DM, 44 had Type 1 DM and 121 had Type 2 DM. Of the patients diagnosed with Type 2 DM, 58 were on insulin and 63 were on oral antidiabetics (OAD). Of 165 patients, 80 (48.50%) had PEY and 85 (51.51%) did not have PEI. The rate of PEI was 59.1% in type 1 DM patients and 44.6% in 121 type 2 DM patients. Patients in the group with severe PEI had a longer diagnostic period and were insulin users. The questionnaire revealed that symptom severity increased as the severity of PEI increased. Results: PEI is a common condition in diabetic patients. Patients diagnosed with diabetes should be evaluated in terms of PEI, PEI symptoms should be questioned, and further examination should be performed when necessary