AFFOLTER, VK

DE COCK, HEV

Ducatelle, Richard

Duchateau, Luc

FERRARO, GL

Govaere, Jan

Van Brantegem, Leen

Abstract: Reasons for performing study: Early diagnosis and monitoring progression of chronic diseases in elastin-rich tissues, such as chronic progressive lymphoedema in draught horses and chronic obstructive pulmonary disease (COPD) is still a real challenge in the horse. Use of an enzyme-linked immunosorbent assay (ELISA) to detect anti-elastin antibody (AEAb) levels might be useful to assess the status of such diseases. Baseline levels, representing physiological breakdown of elastin in normal horses, are not available at present. Hypothesis: Levels of AEAb in healthy horses are generally low and follow the same age-related pattern as found in man. Therefore, elevation of AEAb levels in serum can be used to evaluate pathological elastin breakdown in elastinrich tissues. Methods: Sera of 84 clinically healthy Warmblood horses were evaluated for the presence of AEAbs by means of a modified version of an ELISA technique used in man. The horses were divided in 5 age groups: A) 11 years. Results: Antibodies to elastin were found in all equine serum samples tested. Their levels were lowest in Group A, low in Groups B and E and highest in animals age 210 years. Conclusions: Measuring AEAbs in serum of horses by an ELISA technique proved to be possible and levels were stable during well-defined life stages

van Brantegem, Leen

De Cock, Hilde

Affolter, V.K.

Duchateau, L.

Govaere, J.

Ferraro, G.L.

Ducatelle, R.

Institutional Repository Universiteit Antwerpen

Antibodies to elastin peptides in sera of Warmblood horses at different ages

Ghent University Academic Bibliography

http://sfxit.ugent.be/sfx_local?sid=bellow&atitle=Antibodies%20to%20elastin%20peptides%20in%20sera%20of%20Warmblood%20horses%20at%20different%20ages&issn=0425-1644&volume=39&issue=5&spage=414&date=2007&svc.fulltext=yes

Antibodies to elastin peptides in sera of Warmblood horses at different ages

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Institutional Repository Universiteit Antwerpen

Ghent University Academic Bibliography