Alzheimer\u27s disease is a progressive neurological condition caused by changes in the brain, leading to memory loss, confusion, emotional instability, and cognitive decline. This neurodegenerative disease begins gradually and worsens over time. Initially, damage occurs in the hippocampus and entorhinal cortex, which are crucial areas for memory, resulting in a decrease in brain size. Currently, medical experts, researchers, and scientists are facing challenges in identifying significant brain changes during the early stages of Alzheimer\u27s and as the disease progresses. There is growing global interest in natural remedies, dietary supplements, and functional foods marketed as memory enhancers that may help prevent Alzheimer\u27s and other forms of cognitive decline. However, the claims regarding the safety and effectiveness of these products are largely based on limited testimonials, traditional knowledge, and minimal scientific research. Historically, natural compounds were among the first treatments used for Alzheimer\u27s disease. Comprehensive studies are still needed to fully understand the mechanisms of herbal formulations and to establish appropriate dosages and treatment regimens. The optimal compliance framework consists of five key points: (1) it addresses multiple objectives; (2) it maximizes the impact on each goal; (3) it prevents adverse interactions with other drugs; (4) it has lasting effects and avoids tolerance; and (5) it operates within reasonable limits. We are continuously exploring new herbal formulations within this optimal compliance framework to address complex conditions such as Alzheimer\u27s disease. This article provides a thorough review of Alzheimer\u27s disease and the plants used in its treatment
