Medicinal plants, known for their chemical compounds with pharmacological effects, have been a global and ancient method of treatment. Among them, the genus Artemisia (Asteraceae), with over 300 species, stands out for its therapeutic use throughout history. Artemisia herba-alba, in particular, has long been valued for its effectiveness in treating digestive issues and other ailments, gaining increasing attention for its biological and chemical properties. However, despite their proven effectiveness, probiotics often face challenges in surviving the harsh conditions of the digestive system, highlighting the need for new strategies to enhance their viability and beneficial effects. One promising approach is the integration of probiotics into plant matrices, such as Artemisia herba-alba infusions, which can help preserve the microorganisms and improve the bioavailability of bioactive compounds. This study aims to evaluate the combined effects of an infusion containing ultrabiotic probiotics and Artemisia herba-alba on microbial survival, the bioavailability of active substances, and their post-digestion antioxidant and anti-inflammatory properties. The research is based on a comprehensive review of the literature on plant matrices, probiotics, and Artemisia, followed by experimental validation of these findings. The results offer promising opportunities for enhancing medicinal applications and provide deeper insights into the interactions between probiotics and plant matrices
