LINCLAU, B

Vandewalle, Maurits

The title compound is constructed via Lythgoe's procedure. The crucial steps towards the ''A-ring'' phosphine oxide precursor 5 involve (i)elaboration of the 1,3-trans diol configuration, via stereoselective epoxidation of 8 and (ii) the introduction of the Z-substituted double bond via a highly selective selenation-oxidation-elimination procedure on ester 14

THE SYNTHESIS OF 10,19-DIHYDRO-10-METHYL 1-ALPHA,25-DIHYDROXYVITAMIN D-3.

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