Engine optimization becomes more difficult every day, more and more limits regarding emissions of noxious components have to be met. Considering heavy duty marine engines such as the 6DZC from ABC there are several important instances: IMO III reduces NOx by 75% from 2021, EPA reduces NOx by 70% from 2016. Therefore very complex systems are implemented, which each have multiple calibration or working parameters. Some are fixed, some can change depending on engine load and speed. An example of a fixed parameter is compression ratio, it can only be changed while building the engine. Other fixed parameters include: choice of injection nozzle (#holes, hole-diameter), bore, stroke, etc. Exhaust gas recirculation (EGR) is a parameter that can be changed continuously during operation of the engine. Typically there are other parameters present: Variable Valve Timing, injection timing, injection duration, injection pressure, secondary injection, wastegate setting(s), etc. Ideally these parameters are configured in a way that the engine emits very little harmful components and fuel consumption is very low. The most straightforward approach would be to test every parameter combination, record emission components and fuel consumption and choose the optimal parameter combination. This has to be repeated for every speed and load of the engine, which results in an engine map. This method becomes more and more expensive, both in time as in fuel consumption because every additional operating parameter increases the amount of tests exponentially. This is why engine simulation becomes inevitable. Accurate engine simulation is able to exclude regions of parameter values that are clearly infeasible and can give a good indication where engine tests are more interesting