Antonissen, Gunther

Croubels, Siska

De Baere, Siegrid

Hellebuyck, Tom

Martel, An

Rouffaer, Lieze

Van de Maele, Isabel

English

Ghent University Academic Bibliography

1st International Conference on Avian, Herpetological and Exotic Mammal Medicine April 20-26, 2013 Wiesbaden, Germany Proceedings: p. 427  COMPARATIVE CARBOPLATIN PHARMACOKINETICS IN FOUR DIFFERENT  AVIAN SPECIES  G. Antonissen*, DVM, S. Croubels, Pharm, PhD, S. De Baere, Pharm, PhD,  I. Van de Maele, DVM, Dipl. ECVIM-CA, L. Rouffaer, DVM, T. Hellebuyck, DVM, PhD,  A. Martel, DVM, PhD, Dipl. ECZM (Wildlife population health) .  Faculty of Veterinary Medicine,  Ghent University, Belgium    ABSTRACT  The use of chemotherapy in the treatment of avian neoplasia is largely empirical, and poorly documented. Several chemotherapeutics that are frequently used in canine and feline oncology, have been used in a small number of avian cases with encouraging results. Most of these agents were administered to birds based on mammalian dose rates, because pharmacokinetic data in birds are lacking. Important pharmacokinetic  differences, however, may exist between birds and mammalians, as well as between and within avian orders. The aim of this study was to describe the comparative pharmacokinetics of carboplatin in chickens (Gallus gallus domesticus), ducks (Anas platyrhynchos domesticus), pigeons (Columba livia) and parakeets (Melopsittacus undulates). Respectively 7 chickens, ducks and pigeons and 28 parakeets of one year old were used. Under general inhalation anesthesia carboplatin was administrated intravenously over 3 minutes at a dose of 5mg/kg BW.  Blood was withdrawn at several intervals after the start of the infusion until 24h. Plasma carboplatin concentration were determined using liquid chromatography – mass spectrometry (LC-MS/MS). Pharmacokinetic parameters like area under plasma concentration versus time curve (AUC), volume of central and peripheral compartment, distribution and elimination half-life, and systemic clearance were determined. Results showed a two compartimental model with a significant larger peripheral compartment in chickens than in ducks and pigeons (P=0.002). The systemic clearance was significant higher in pigeons than in chickens and ducks (P<0.001). The elimination half-life was significant longer in chickens than in ducks and pigeons (P=0.006). Carboplatin was eliminated slower in chickens compared to ducks and pigeons.    AUTHOR ADDRESS:  G. Antonissen, DVM Department of Pathology, Bacteriology and Poultry Diseases and Department of Pharmacology, Toxicology and Biochemistry Faculty of Veterinary Medicine Ghent University, Salisburylaan 133 9820 Merelbeke Belgium e-mail: Gunther.Antonissen@UGent.be    

Comparative carboplatin pharmacokinetics in four different avian species

https://biblio.ugent.be/publication/3202456/file/3202464

Comparative carboplatin pharmacokinetics in four different avian species

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Ghent University Academic Bibliography