Synthetic fibres form an important part of the textile industry, the production of poly(ethylene terephthalate) (PET) alone surpassing that of cotton. A disadvantage of synthetic fibres is their low hydrophilicity. Polyester fibres are particularly hydrophobic. This affects the processability and functionalisation of the fibres. A novel and promising alternative is the use of enzymes in surface modification of synthetic fibres. Synthetic materials have generally been considered resistant to biological degradation; recent developments at different research groups demonstrate that enzymes are very well capable of hydrolysing synthetic materials