When subjected to cyclic loads, fatigue cracks can cause failure of pipe systems joined by threaded pipe connections. In this study, the effect of contact conditions and coupling geometry is investigated experimentally. Fatigue tests under cyclic bending are carried out on three different threaded connection configurations. The resulting fatigue lives are compared and fracture surfaces are investigated. The fatigue cracks are found to initiate at the last engaged thread of the pin and fatigue life can be increased by applying PTFE tape or changing the coupling geometry