Van Reeth, Kristien

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Ghent University Academic Bibliography

The European Surveillance Network for Influenza in Pigs: ESNIP Prof Kristien Van Reeth Ghent University, Belgium OFFLU Technical Meeting, Paris 6-7 April 2011 ESNIP’s are EC-funded “co-ordination actions” Dec ‘00 – March ‘04 269 984 € 14 partners coördinator Guus Koch Jan ‘06 – March ‘09 300 000 € 11 partners coördinator Kristien Van Reeth Nov ‘10 – Nov ’13 1 000 000 € 23 partners coördinator Ian Brown ESNIP 1 ESNIP 2 ESNIP 3 Swine influenza situation in 1999 • Antigenic drift in H3N2 SIVs from The Netherlands and Belgium reported by some researchers,       not by others • Emergence of a novel H1N2 reassortant               (with human-like HA) in the UK in 1994 • Sudden change in SI epidemiology in the US in 1998:      triple reassortant H3N2 viruses • Cases of H5 and H9 avian influenza humans in    Hong Kong; growing concerns about potential role of pigs as intermediate hosts   ESNIP1 - Major achievements   1 Standardization of protocols for diagnosis  1 Selection of reference virus strains, production of hyperimmune sera  2 Establishment of a central virus bank and an electronic database  3 Antigenic & genetic characterization of some recent isolates  4 Preliminary picture of prevalence of different SIV subtypes in different countries ESNIP2 – Work packages 2 1 5 4 3 ZPH 2011, Vol 58:93-101 ESNIP2 • 169 SIVs isolated (2006 to 2008) • H1N1, H3N2 and H1N2 in Belgium, Italy, Spain • No H3N2 in UK or France • 97% “prototype” European SIVs  • only 5 “novel” reassortants   (2 H1N1 and 3 H1N2) H1N1  49% (83) H1N2  30% (50) H3N2  21% (36) Strong antigenic relationship between older human H1N1  and H3N2 viruses (1980s) and current swine H1N2 and H3N2  (common origin!), but not with more recent human viruses. ESNIP2 - Major achievements   1 Antigenic and genetic characterization of a (limited) number of European SIVs  2 Serological profile of fatteners in 80 farrow-to-finish herds (Belgium, France, Italy, Spain) to determine infection pattern  3 M gene-targeted real time RT-PCR for SIV established  4 Expansion of virus bank  1 Serologic investigations to determine cross-reactivity between 2009 pH1N1 virus and existing European SIVs  ESNIP3 – What next? 1. Whole genome sequencing 2. Antigenic mapping using cartography 3. Virus bank will be made publicly available at end of project   ESNIP3 - participants P1:     Veterinary Laboratories Agency (VLA) UK P2:     Ghent University (UGent) BELGIUM P3:     French Agency for Food, Environmental and Occupational Health (AFSSA) FRANCE P4:     Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna             (IZSLER) ITALY P5:     Technical University of Denmark DENMARK  P6:     Panstwowy Instytut Weterynaryjny POLAND P7:     Laboratorio Central Veterinario-Sanidad Animal SPAIN P8:     IDT Biologika GmbH GERMANY P9:     Finnish Food Safety Authority EVIRA FINLAND P10:   Kimron Veterinary Institute ISRAEL P11:   Veterinary Diagnostic Directorate HUNGARY ESNIP3 - participants P12:   Central Veterinary Institute of Wageningen THE NETHERLANDS P13:   University of Thessaly GREECE P14:   Wellcome Trust Sanger Institute UK P15:   University of Cambridge UK   P16:   University of Oxford UK  P17:   Friedrich Loeffler Institute GERMANY P18:   Istituto Zooprofilattico Sperimentale dele Venezie ITALY P19:   St. Jude Children’s Research Hospital USA P20:   United States Department of Agriculture USA P21:   Harbin Veterinary Institute CHINA P22:   MERIAL, Virology Department (MERIAL) FRANCE P23:   Laboratorios HIPRA S.A. (HIPRA) SPAIN P24:   Animal Health Trust UK Challenges to surveillance • Difficult access to samples, passive >> active surveillance, fragmented data analysis  • Standardization of protocols is a must  • Resources and time  • More international harmonization and coordination of surveillance needed     Thanks to the European Commission  and all ESNIP partners 

The European surveillance network for influenza in pigs: ESNIP

https://biblio.ugent.be/publication/2048183/file/2048184

The European surveillance network for influenza in pigs: ESNIP

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Ghent University Academic Bibliography