This article explores the clinical and pathophysiological relationship between gastroesophageal reflux disease (GERD) and chronic laryngitis, emphasizing diagnostic challenges, mechanisms of mucosal injury, and treatment outcomes. GERD is a prevalent gastrointestinal disorder caused by retrograde flow of gastric contents into the esophagus, which can extend to the laryngopharyngeal area, resulting in extra-esophageal manifestations such as chronic laryngitis, hoarseness, cough, and throat clearing. The study analyzes clinical data to determine the frequency of laryngeal inflammation secondary to GERD, investigates the role of pepsin and acid exposure in mucosal damage, and evaluates the therapeutic effectiveness of proton pump inhibitors (PPIs) and lifestyle modifications. Results confirm a strong association between GERD and chronic laryngitis, with a significant proportion of patients exhibiting symptomatic improvement after antireflux therapy. The findings underscore the importance of multidisciplinary management involving otolaryngologists and gastroenterologists for optimal patient outcomes
