Bougarne, Nadia

Delgado, Rene

Garcia-Rivera, Dagmar

Haegeman, Guy

Vanden Berghe, Wim

Ghent University Academic Bibliography

Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells

Abstract: Vimang is a standardized extract derived from Mango bark (Mangifera Indica L.), commonly used as anti-inflammatory phytomedicine, which has recently been used to complement cancer therapies in cancer patients. We have further investigated potential anti-tumour effects of glucosylxanthone mangiferin and indanone gallic acid, which are both present in Vimang extract. We observed significant anti-tumour effects of both Vimang constituents in the highly aggressive and metastatic breast cancer cell type MDA-MB231. At the molecular level, mangiferin and gallic acid both inhibit classical NF\u3baB activation by IKK\u3b1/\u3b2 kinases, which results in impaired I\u3baB degradation, NF\u3baB translocation and NF\u3baB/DNA binding. In contrast to the xanthone mangiferin, gallic acid further inhibits additional NF\u3baB pathways involved in cancer cell survival and therapy resistance, such as MEK1, JNK1/2, MSK1, and p90RSK. This results in combinatorial inhibition of NF\u3baB activity by gallic acid, which results in potent inhibition of NF\u3baB target genes involved in inflammation, metastasis, anti-apoptosis and angiogenesis, such as IL-6, IL-8, COX2, CXCR4, XIAP, bcl2, VEGF. The cumulative NF\u3baB inhibition by gallic acid, but not mangiferin, is also reflected at the level of cell survival, which reveals significant tumour cytotoxic effects in MDA-MB231 cells. Altogether, we identify gallic acid, besides mangiferin, as an essential anti-cancer component in Vimang extract, which demonstrates multifocal inhibition of NF\u3baB activity in the cancer-inflammation network

Garc\ueda-Rivera, Dagmar

Delgado, Ren\ue9

Institutional Repository Universiteit Antwerpen

Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of **Mangifera indica** L. bark in MDA-MB231 breast cancer cells

Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells

Abstract

Similar works

Full text

Available Versions

Ghent University Academic Bibliography

Institutional Repository Universiteit Antwerpen