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Novel dressing materials accelerating wound healing made from dibutyrylchitin

Abstract

Dibutyrylchitin (DBC), a soluble chitin derivative, is a polymer with confirmed biological properties. DBC was obtained in the reaction of shrimp chitin with butyric anhydride, carried out under heterogeneous condition, in which perchloric acid was used as a catalyst of reaction. Production of DBC batches was carried out on a half - technical scale line. If DBC parties were examined by infrared spectrometry, size exclusion chromatography and viscometry. DBC with molar mass of 132 x 10(3) daltons was used for the manufacturing of DBC fibres and DBC non-woven materials. DBC non-woven fabrics after gamma-sterilisation were applied to a group of nine patients with different indications. DBC dressing materials were used exluding the use of other medical products. Satisfactory results of wound healing were achieved in most cases, especially in cases of burn wounds and postoperative/posttraumatic wounds and various other conditions causing skin/epidermis loss

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