van Elteren, Johannes T

Van Malderen, Stijn

Vanhaecke, Frank

English

Ghent University Academic Bibliography

Combination of a fast ablation cell and deconvolution approachesfor high resolution LA-ICP-MS scanning of layered materialsStijn J. M. Van Malderen1 Johannes T. van Elteren2 Frank Vanhaecke11 Department of Analytical Chemistry, Ghent University, Krijgslaan 281 - S12, Ghent, BE-9000, Belgium2 Analytical Chemistry Laboratory, National Institute of Chemistry, Hajdrihova 19, Ljubljana,SI-1000, , , SloveniaIn recent years, LA-ICP-MS has proven to be a valuable tool in the visualization of the spatialdistribution of nuclides on a µm-level in a wide variety of sample types and applications fields. Thelateral resolution achievable in a scanning approach is restricted by (i) the extent of overlap ofpeak responses, (ii) peak broadening by impaired aerosol dispersion, (iii) limitations imposed onthe accuracy of the response and sampling speed of the MS configuration and detector, (iv) theaccuracy and velocity of the translation stage which traverses the laser beam over the samplesurface, and (v) the radius of the beam waist of the focused laser beam, which in turn is limited bythe diffraction limit in the far field, or the lack of sensitivity for the targeted nuclides. Thisfundamental study pursuits a combined strategy of ablation cell development and post-acquisitionmethodology for enhancing the sensitivity, spatial resolution and throughput capabilities of LA-ICP-MS beyond state-of-the art1,2. The novel laser ablation tube-cell and transport assemblydeveloped are characterized by exceptional aerosol dispersion behaviour, enabling discrete pulseresponses at pulse repetition rates up to 200-300 Hz.3 The design reported was derived fromconsiderations of data produced by computational fluid dynamics and plasma shockwavereflection simulations. Furthermore, an iterative Richardson-Lucy deconvolution approach,capable of resolving features below the physical size of the laser beam projected onto the samplesurface, was adopted. The algorithm derives the initial lateral nuclide distribution by correcting thedistortion in the response profile upon oversampling a feature. The strategy demonstrated a lateralresolution in the order of 0.3 ± 0.1 micrometre for scanning of micrometre-sized layers in multi-layer ceramic capacitors by overlapping the ablation positions of a 1 micrometre diameter laserbeam.(1) Wang, H. A.; Grolimund, D.; Giesen, C.; Borca, C. N.; Shaw-Stewart, J. R.; Bodenmiller, B.;Gunther, D.; Anal Chem 2013, 85, 10107-10116.(2) Managh, A. J.; Edwards, S. L.; Bushell, A.; Wood, K. J.; Geissler, E. K.; Hutchinson, J. A.;Hutchinson, R. W.; Reid, H. J.; Sharp, B. L.; Anal Chem 2013, 85, 10627-10634.(3) Van Malderen, S. J. M.; van Elteren, J. T.; Vanhaecke, F.; J. Anal. At. Spectrom 2014, DOI:10.1039/c4ja00137k.

Combination of a fast ablation cell and deconvolution approaches for high resolution LA-ICP-MS scanning of layered materials

https://biblio.ugent.be/publication/7056724/file/7056774

Combination of a fast ablation cell and deconvolution approaches for high resolution LA-ICP-MS scanning of layered materials

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