Concordet, Didier

Croubels, Siska

Daminet, Sylvie

Lefebvre, Hervé P

Paepe, Dominique

Smets, Pascale

van Hoek, Ingrid

English

Ghent University Academic Bibliography

ABSTRACT #31 2010 ACVIM Forum Abstracts p.679  LIMITED SAMPLING STRATEGIES TO ESTIMATE GLOMERULAR FILTRATION RATE IN CATS WITH LOW, NORMAL AND HIGH GLOMERULAR FILTRATION RATES D. Paepe1, H.P. Lefebvre2, D. Concordet2, I. vanHoek1, P.Smets1, S. Croubels1, S. Daminet1 1Ghent University, Ghent, Belgium.2National Veterinary School of Toulouse, Toulouse, France. Limited sampling strategies (LSS) to estimate feline glomerular filtration rate (GFR) are poorly documented and mainly assessed in healthy cats and/or using only one clearance marker. This study aimed to propose LSS in cats with normal, decreased and increased GFR for plasma exo-iohexol, endo-iohexol and creatinine clearance. A combined plasma exogenous creatinine-iohexol clearance test was performed in 44 cats (16 hyperthyroid, 6 diabetic, 12 healthy, 10 with chronic kidney disease). The best LSS was determined by comparing 510 sampling time combinations to the entire 9 blood sampling times set for calculating AUC values by the trapezoidal rule. The maximum error was calculated for each best sampling timecombination. Optimal sampling times for 2-sample plasma clearance are 60 and 360 minutes for endo-iohexol and 60 and 480 minutes for creatinine and exo-iohexol, with a maximum error of -36.9%, -24.6% and 33.8%, respectively. Optimal sampling times for 3-sample plasma clearance are 30, 180 and 600 minutes for creatinine and 30, 120 and 480 minutes for exo- and endo-iohexol, with a maximum error of 11.4%, -18.2% and 18.2%, respectively. Blood sampling timing is GFR marker dependent. The GFR estimate is more accurate for 3-sample compared to 2-sample plasma clearance for all markers. The error observed on GFR estimate was lower for LSS using creatinine as GFR marker. 

Limited sampling strategies to estimate glomerular filtration rate in cats with low, normal and high glomerular filtration rates

https://biblio.ugent.be/publication/1231378/file/1231551

Limited sampling strategies to estimate glomerular filtration rate in cats with low, normal and high glomerular filtration rates

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Ghent University Academic Bibliography