Hibiscus rosa-sinensis has been traditionally used by local communities to treat fever. However, there are only limited data have been published to support the antipyretic effects. The objective of this study is to investigate the antipyretic properties and possible mechanism of the ethanol extracts of Hibiscus rosa-sinensis L. (red) and Hibiscus rosa-sinensis var. Alba (white) flower and leaf. Phytochemical analysis, heavy metals screening and acute toxicity test were done to evaluate the safety of extracts. The first model ran induced fever in rats by injecting Brewer's Yeast subcutaneously and then treated with 4 extracts at dosage 5 & 50 mg/kg. The dosages used for the study were obtained by the acute toxicity test. Ibuprofen was used as a reference drug, with dose 100 mg/kg. The results of the study showed that white flower extract 5 mg/kg and 50 mg/kg significantly (p0.05) decrease of PGE2 when compared to control. Therefore, this research suggest the probability for its therapeutic effectiveness as plant-based antipyretic agent as claimed by traditional medicine practitioners of our local community
