This study was carried out to evaluate the antioxidative potential and quality of the meat of African catfish fed mulberry foliage extract (MFE). A total of 360 juvenile African catfish (8.4 ± 0.2 g) were fed four diets namely, basal diet (control), MFE-2 (2 g MFE kg−1), MFE-5 (5 g MFE kg−1) and MFE-7 (7 g MFE kg−1) for 60 days. At the end of the experiment, muscles were excised, vacuum-packaged and conditioned for 0, 7 and 14 days in a chiller (4°C). The meat from fish fed MFE-5 and MFE-7 had significantly (P < 0.05) greater total phenols content than the other dietary groups. This value reduced (P < 0.05) during storage. The DPPH-scavenging effect of MFE-7 increased (P < 0.05) compared with the others. It decreased (P < 0.05) during storage. The lowest POV was revealed (P < 0.05) in MFE-7. The 2-thiobarbituric acid-reactive substances (TBARS) and peroxide value (POV) increased (P < 0.05) during storage. The pH value was significantly (P < 0.05) higher in MFE supplemented diets than in the control group. It is concluded that MFE at the concentration of 7 g kg−1 DM is potential dietary antioxidant supplements, to improve the quality of fish meat