Meeting Abstract from the 13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT)
Vienna, Austria. 22\u201324 November 200

Bursch, Wilfried

Ferk, Franziska

Fuerhacker, Maria

Hann, Stephan

K\uf6llensperger, Gunda

Knasm\ufcller, Siegfried

Krenn, Petra

Lenz, Katharina

Mader, Robert M

Mahnik, Susanne N

Uhl, Maria

Weissenbacher, Norbert

Meeting Abstract from the 13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT)
Vienna, Austria. 22–24 November 200

Köllensperger, Gunda

Knasmüller, Siegfried

Publikationsserver der Fachhochschule (FH) Campus Wien

BMC Pharmacology / Hospital waste water: health risk for human and environment by cytostatic drug emissions? Part II: Biological monitoring (genotoxicity assays) and risk assessment

Franziska Ferk

Maria Uhl

Maria Fuerhacker

Susanne N Mahnik

Katharina Lenz

Norbert Weissenbacher

Robert M Mader

Petra Krenn

Stephan Hann

Gunda Koellensperger

Siegfried Knasmüller

Wilfried Bursch

Springer - Publisher Connector

BioMed Central
Page 1 of 1
(page number not for citation purposes)
BMC Pharmacology
Open AccessMeeting abstract
Hospital waste water: health risk for human and environment by 
cytostatic drug emissions? Part II: Biological monitoring 
(genotoxicity assays) and risk assessment
Franziska Ferk1, Maria Uhl2, Maria Fuerhacker3, Susanne N Mahnik1,3, 
Katharina Lenz3, Norbert Weissenbacher3, Robert M Mader1, Petra Krenn1, 
Stephan Hann3, Gunda Koellensperger3, Siegfried Knasmüller1 and 
Wilfried Bursch*1
Address: 1Institute of Cancer Research, Clinics of Internal Medicine I, Medical University of Vienna, Austria, 2Umweltbundesamt, Vienna, Austria 
and 3BOKU University of Natural Resources and Applied Life Sciences, Vienna, Austria
Email: Wilfried Bursch* - wilfried.bursch@meduniwien.ac.at
* Corresponding author    
Biological monitoring
Assays: (a) Bacterial mutagenicity (TA98, TA100), (b) sin-
gle cell gel electrophoresis (SCGE; endpoint: DNA migra-
tion) with primary rat hepatocytes. Waste water samples:
effluent of (a) the total hospital (TH), (b) the oncological
ward (OW), collected before dilution in the Vienna sewer
system.
Results
All samples negative in bacterial assays, acute bacterio-
cidal/bacteriostatic effects of highest water volumes
tested. SCGE assays:  increase but no significant differences
between DNA migration caused by TH and OW samples.
The genotoxic activities of the waters could be reduced sig-
nificantly (25–50%) by waste water treatment.
Risk assessment
according to EU Guidelines aimed at elucidating priorities
and urgencies for risk management. Integrating chemical
and biological monitoring data, genotoxic profile and
(sparse) data on aquatic toxicity revealed that the endan-
germent of humans, aquatic and terrestrial environment
by cytostatic drugs released via hospital waste water could
be preliminary classified as small. A reduction of the
avoidable environmental load – in line with EU docu-
ment 2000/60/EC – could be achieved by advanced waste
water treatment at the source as applied within the frame-
work of this project.
from 13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the 
Hungarian Society for Experimental and Clinical Pharmacology (MFT)
Vienna, Austria. 22–24 November 2007
Published: 14 November 2007
BMC Pharmacology 2007, 7(Suppl 2):A70 doi:10.1186/1471-2210-7-S2-A70
<supplement> <title> <p>13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT)</p> </title> <editor>Ernst Singer and Thomas Griesbacher</editor> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="[http://www.biomedcentral.com/content/files/pdf/1471-2210-7-S2-full.pdf]">here</a></note> <url>http://www.biomedcentral.com/content/pdf/1471-2210-7-S2-info.pdf</url> </supplement>
This abstract is available from: http://www.biomedcentral.com/1471-2210/7/S2/A70
© 2007 Ferk et al; licensee BioMed Central Ltd. 


Hospital waste water: health risk for human and environment by cytostatic drug emissions? Part II: Biological monitoring (genotoxicity assays) and risk assessment

Publikationsserver der Universitätsbibliothek Bodenkultur Wien

BioMed CentralPage 1 of 1(page number not for citation purposes)BMC PharmacologyOpen AccessMeeting abstractHospital waste water: health risk for human and environment by cytostatic drug emissions? Part II: Biological monitoring (genotoxicity assays) and risk assessmentFranziska Ferk1, Maria Uhl2, Maria Fuerhacker3, Susanne N Mahnik1,3, Katharina Lenz3, Norbert Weissenbacher3, Robert M Mader1, Petra Krenn1, Stephan Hann3, Gunda Koellensperger3, Siegfried Knasmüller1 and Wilfried Bursch*1Address: 1Institute of Cancer Research, Clinics of Internal Medicine I, Medical University of Vienna, Austria, 2Umweltbundesamt, Vienna, Austria and 3BOKU University of Natural Resources and Applied Life Sciences, Vienna, AustriaEmail: Wilfried Bursch* - wilfried.bursch@meduniwien.ac.at* Corresponding author    Biological monitoringAssays: (a) Bacterial mutagenicity (TA98, TA100), (b) sin-gle cell gel electrophoresis (SCGE; endpoint: DNA migra-tion) with primary rat hepatocytes. Waste water samples:effluent of (a) the total hospital (TH), (b) the oncologicalward (OW), collected before dilution in the Vienna sewersystem.ResultsAll samples negative in bacterial assays, acute bacterio-cidal/bacteriostatic effects of highest water volumestested. SCGE assays:  increase but no significant differencesbetween DNA migration caused by TH and OW samples.The genotoxic activities of the waters could be reduced sig-nificantly (25–50%) by waste water treatment.Risk assessmentaccording to EU Guidelines aimed at elucidating prioritiesand urgencies for risk management. Integrating chemicaland biological monitoring data, genotoxic profile and(sparse) data on aquatic toxicity revealed that the endan-germent of humans, aquatic and terrestrial environmentby cytostatic drugs released via hospital waste water couldbe preliminary classified as small. A reduction of theavoidable environmental load – in line with EU docu-ment 2000/60/EC – could be achieved by advanced wastewater treatment at the source as applied within the frame-work of this project.from 13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT)Vienna, Austria. 22–24 November 2007Published: 14 November 2007BMC Pharmacology 2007, 7(Suppl 2):A70 doi:10.1186/1471-2210-7-S2-A70<supplement> <title> <p>13th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint Meeting with the Austrian Society of Toxicology (ASTOX) and the Hungarian Society for Experimental and Clinical Pharmacology (MFT)</p> </title> <editor>Ernst Singer and Thomas Griesbacher</editor> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="[http://www.biomedcentral.com/content/files/pdf/1471-2210-7-S2-full.pdf]">here</a></note> <url>http://www.biomedcentral.com/content/pdf/1471-2210-7-S2-info.pdf</url> </supplement>This abstract is available from: http://www.biomedcentral.com/1471-2210/7/S2/A70© 2007 Ferk et al; licensee BioMed Central Ltd. 

file:///data/core-remote/dit/data/Springer-OA/pdf/ea4/aHR0cDovL2xpbmsuc3ByaW5nZXIuY29tLzEwLjExODYvMTQ3MS0yMjEwLTctUzItQTcwLnBkZg==.pdf

BMC Pharmacology / Hospital waste water: health risk for human and environment by cytostatic drug emissions? Part II: Biological monitoring (genotoxicity assays) and risk assessment

Abstract

Similar works

Full text

Available Versions

Publikationsserver der Fachhochschule (FH) Campus Wien

Springer - Publisher Connector

Springer - Publisher Connector

Publikationsserver der Universitätsbibliothek Bodenkultur Wien