Background: The Rab13-JRAB system transports cell adhesion molecules.
Results: JRAB interacts with actinins and F-actin and spatiotemporally regulates actin dynamics via a conformational change that is dependent upon Rab13.
Conclusion: Rab13 and JRAB regulate reorganization of the actin cytoskeleton throughout epithelial junctional development from establishment to maturation of cell-cell adhesion.
Significance: The Rab13-JRAB system may simultaneously coordinate vesicle transport and actin cytoskeletal organization.journal articl
