Chistyakov, A.V.

Corbetta, M.

Gekhman, A.E.

Manenti, F.

Tsodikov, M.V.

Zharova, P.A.

Zharova, P. A.

Chistyakov, A. V.

Tsodikov, M. V.

Gekhman, A. E.

MANENTI, FLAVIO

Archivio istituzionale della ricerca - Politecnico di Milano

 CHEMICAL ENGINEERING TRANSACTIONS   VOL. 43, 2015 A publication of  The Italian Association of Chemical Engineering Online at www.aidic.it/cet Chief Editors: Sauro Pierucci, Jiří J. Klemeš Copyright © 2015, AIDIC Servizi S.r.l., ISBN 978-88-95608-34-1; ISSN 2283-9216                                                                                Cross-Coupling of Bio-oxygenates over Heterogeneous Catalysts Polina A. Zharovaa,b, Andrey V. Chistyakova,b, Mark V. Tsodikova,b, Alexander E. Gekhmanb, Michele Corbettac, Flavio Manentic a A.V. Topchuev Institute of Petrochemical Synthesis, Leninskiy prospect, 29, Moscow, 119991, Russian Federation b Moscow Institute of Physics and Technology, 9 Institutskiy per., Dolgoprudny, Moscow Region, 141700, Russian Federation c Politecnico di Milano, Dipartimento di Chimica, Materiali e Ingegneria Chimica “Giulio Natta”, Piazza Leonardo da Vinci, 32, 20133 Milano, Italy zharova@ips.ac.ru The importance of synthesis of carbon-carbon bonds is reflected by the fact that Nobel Prizes in Chemistry have been given to this area: The Grignard reaction (1912), the Diels-Alder reaction (1950), the Witting reaction (1979), the olefin metathesis Y. Chauvin, R.H. Grubbs and R.R. Schrock (2005), the palladium-catalyzed cross-coupling reactions to R. F. Heck, A. Suzuki, E. Negishi. Here, we present the new heterogeneous catalytic cross-coupling reaction of a number of bio-oxygenates that lead to expand considerably the hydrocarbons incorporating. For catalytic experiments, mono- and bimetallic Pt-M and Re-M were used. As substrates we used ethanol (the most shared bioalcohol), glycerol (co-product of biodiesel production), n-butanol, propanol and acetone (prospective bioproducts) and vegetable oil.  It was found that the main products of ethanol conversion are alkanes with even number of carbon atoms. When we used C3 co-reagents (propanol, acetone, glycerol) products composition was enriched with hydrocarbons with odd number of carbon atoms. That gave us a reason to propose cross-coupling reactions take place during combined conversion of bio-oxygenates. Glycerol was found to be the best co-reagent to ethanol. Its addition (not more than 40 wt.%) to ethanol halves C1-C2 yields and increases hydrocarbons yield by 20-30 wt.% in comparison with pure ethanol conversion products. 1. Introduction Nowadays, a significant interest has been concentrated on effective approaches related to renewable biomass conversion to fuels (Ragauskas et. al., 2006). Ethanol, butanol, iso-propanol, n-propanol and acetone (by-product of fermentation butanol production) produced via the fermentation of biomass.  Glycerol is generated in large quantities as a by-product of the triglycerides transesterification (Gude et. al., 2013). All of this bio-oxygenates can be incorporated into gasoline and biodiesel, either directly or after catalytic conversion into more effective additives. Earlier the new catalytic reaction of alcohol conversion towards hydrocarbons of gasoline and diesel fractions was found (Tsodikov et. al., 2004). This reaction named reducing dehydration of alcohols proceeds in an inert atmosphere Eq.1. Hydrogen required for alkane formation was formed via parallel reactions of partial ethanol dehydration and/or aromatization. nC2H5OH + H2 → C2nH4n+2 + nH2O         (1) In process of developing of reducing dehydration of alcohols reaction a possibility was found to carry on combined conversion of ethanol with cyclopentanol into alkyl substituted cycloalkanes (Eq.2) over Pt/Al2O3 catalyst (Tsodikov et. al., 2008). Also Pt-containing catalysts showed high activity and selectivity in the reaction of ethanol conversion towards fuel hydrocarbons (Tsodikov et. al., 2014). The importance of synthesis of carbon-carbon bonds is reflected by the fact that Nobel Prizes in Chemistry have been given to this area: The Grignard reaction (1912), the Diels-Alder reaction (1950), the Witting                                                                                          DOI: 10.3303/CET1543070                                                             Please cite this article as: Zharova P., Chistyakov A., Tsodikov M., Gekhman A.E., Corbetta M., Manenti F., 2015, Cross-coupling of biooxygenates over heterogeneous catalysts, Chemical Engineering Transactions, 43, 415-420  DOI: 10.3303/CET1543070415reaction (1979), the olefin metathesis (Chauvin et al., 2005), the palladium-catalyzed cross-coupling reactions to R. F. Heck, A. Suzuki, E. Negishi (Astruc, 2011). OH+ EtOHRR (2) where R = C2H5; C2H3; C3H7; C4H9 Here, we present the new heterogeneous catalytic cross-coupling reaction of a number of bio-oxygenates that lead to expand considerably the hydrocarbons incorporating.  2. Materials and Methods Analytical grade ethanol (96 %) was used without further purification. For catalytic experiments, industrial Pt-containing catalysts samples (Pt/Al2O3, PR-56, Pt-Re/Al2O3) were used. The cross-coupling reaction of bio-oxygenates was performed in a flow-circulation unit with a stationary catalyst layer under argon at 623 K, 5 bar, VHSV (volume hours space velocity) 0.6 h-1, and a multiplicity of gas circulation of 50 cm3/min. Qualitative and quantitative analyses of the C1–C5 hydrocarbon gases were performed by gas-liquid chromatography (GLC) with a Kristall-4000M chromatograph (detector: FID, carrier gas: He, column: HP-PLOT/Al2O3, 50 m × 0.32 mm). GLC analyses of CO, CO2 and H2 were performed with a Kristall-4000 chromatograph (detector: TCD, carrier gas: Ar, column: SKT, 1.5 m × 4 mm). The qualitative composition of the C6+ hydrocarbons in the aqueous and organic phases were identified by gas chromatography–mass spectrometry (GC-MS) using a MSD 6973 - and an Automass-150 spectrometer - (EI = 70 eV, sample volume = 1 µl, columns: HP-5MS, 50 m × 0.32 mm and CPSil-5, 25 m × 0.15 mm). The quantitative content of the organic compounds was determined by GLC using a Varian 3600 chromatograph (detector: FID, carrier gas: He, column: Chromtec SE-30, 25 m × 0.25 mm). Trifluoromethyl benzene was used as an internal standard for the organic layer, and internal normalization was used for the aqueous layer. The ethanol content in the aqueous phase was determined by GC-MS using the absolute calibration method on the ratio of alcohol to water integral signals. 3. Results and Discussion Cross-coupling of ethanol and a number of bio-oxygenates was investigated over 1.5%Re-3.5%W/Al2O3 catalyst. It was found that glycerol provide the maximum increasing of C3+ hydrocarbons fraction yield, up to 57%, and that is the most suitable co-reagents for use with ethanol (Table 1).  Table 1: Composition (wt.%) of carbon containing products of ethanol and various bio-oxygenates mixture conversion under optimal conditions over 1,5Re-3,5%W/Al2O3 catalyst   EtOH EtOH+20vol.%PrOH EtOH+20 vol.%BuOH EtOH+20 vol.%Glycerol С1 0.1 2.2 0.1 2.0 С2 8.8 14.9 9.9 4.0 С2= 20.2 16.5 17.9 1.9 С3 0.1 0.5 0.1 0.3 С3= 0.8 1.9 1.2 7.9 С4 4.4 12.5 6.7 0.7 С4= 17.7 12.5 24.8 18.1 С5 0.8 11.0 0.2 1.2 С5= 0.2 4.5 0.3 9.3 С6 0.7 0.7 1.1 0.7 С6= 6.1 6.5 11.1 13.7 С7= - 3.0 0.0 2.3 С8= 1.2 0.7 3.2 1.7 C9= - - - 1.1 ƩC3+ 31.8 53.8 48.7 56.9 416Influence of glycerol concentration for products composition was investigated. As shown in Table 2 the optimal glycerol concentration for its conversion with ethanol is 20 vol.%. An excess of 20 vol.% concentration of glycerol content in feeding mixture leads to decrease yield of aim fraction (C3+ hydrocarbons), unspecified nonvolatile substances formation and catalyst coking. With further increase of the glycerol proportion in the reaction mixture the selectivity drastically changes: instead of aliphatic hydrocarbons the nondescript mixture of oxygenates are formed. Also acrolein- a product of the thermal decomposition of glycerol - polymerize to resins. Table 2: Composition (wt.%) of carbon containing products of ethanol and various concentration of glycerol mixture conversion under optimal conditions over 1.5%Re-3.5%W/Al2O3 catalyst. EtOH+ 20 vol.% Glycerol 40 vol.%Glycerol С1 1.95 4 С2 4.01 1.25 С2= 1.93 2.41 С3 0.25 0.25 С3= 7.9 3.1 С4 0.7 0.8 С4= 18.11 12.5 С5 1.2 - С5= 9.26 9.2 С6 0.7 - С6= 13.7 8.8 С7= 2.3 3.8 С8= 1.7 1.7 C9= 1.1 1.85 ƩC3+ 56.9 42.0 Ethanol and glycerol mixture conversion was investigated over wide number of catalysts. As shown in Table 3 yield of hydrocarbons C3+ about the same, but glycerol contribution in cross-coupling products formation over Pt-Re/Al2O3 catalyst exceeds 60%. So It may be predicted that Pt-Re/Al2O3 catalyst is the most prospective for further investigations of cross-coupling process over heterogeneous catalysts. Table 3: Ethanol and glycerol mixture conversion under optimal conditions over wide number of catalysts catalyst Yield С3+, wt.% % glycerol in С3 % glycerol cross Pt-Re/Al2O3 53.2 31.5 62.2 1,5Re-3,5%W/Al2O3 49.8 3.8 24.2 Ta-Re/Al2O3 57.4 16.6 28.4 Ga/Al2O3 57.1 23.8 29.1 Cu/Al2O3 60.1 8.0 23.8 0,1Au-0,003Ni/Al2O3 61.3 21.2 28.2 To test Pt-Re/Al2O3 catalyst selectivity in cross-coupling reaction it was carried out combine ethanol with different alcohols conversion. The criterion of reaction efficiency was the ratio of primary products according to Eq. 3 yield to ones obtained via pure ethanol conversion.  (3) EtOH + X* Pt-Re/Al2O3350° С, 5 atm Ar С5 С7 С8 +EtOH +X* 417* - X substrate С3 (propanol, acetone, glycerol, propene)  Data of catalytic experiments shows that cross-coupling products yield increases in 1-3 orders depending on co-reagent (Table 4). The highest efficiency was observed for C5 formation and decreased from C7 to C8. The reason of low ratio C8/C8 EtOH may be explained with ethanol can form C8 by itself. Acetone was found to be the most active co-reagent with ethanol. Primary cross-coupling products yield was maximum during acetone and ethanol conversion. Table 4: Mole ratio of the yield of primary cross-coupling products obtained via combined conversion of bio-oxygenates with ethanol to yield of ones obtained via ethanol conversion over Pt-Re/Al2O3 catalyst    C5/C5 EtOH C7/C7 EtOH C8/C8 EtOH EtOH+nPrOH (40%)  697 94 12 EtOH+iPrOH (50%)  141 35 2 EtOH+Acetone(40%)  1166 429 43 EtOH+Glycerol (20%)  616 177 21 Table 5: Composition (wt.%) of carbon containing products of ethanol and various concentration of acetone mixture conversion under optimal conditions over Pt-Re/Al2O3 catalyst  Acetone vol.% Сonversion products 100 50 40 20 10 0 C1 1.2 6.5 2 7.9 8.6 7.7 C2 1 6.9 3.3 21.1 25.9 31.2 C3 11.3 18.2 8.4 13.3 12.5 6.6 C4 6.8 11.2 5.6 8.3 10.2 20.7 C5 8.1 11.8 13.5 7.8 4.4 3.9 C6 - - 1.1 2.5 2.9 8 C7 - - 16.3 5.5 3.9 1.6 C8 - - 5.7 4.1 1.7 1.9 C9 - - 0.3 2.6 3 0.6 C10 - - - 1.4 0.6 0.3 C11 - - - 1.3 0.8 0.1 C12 - - - 0.7 0.7 -  ƩС3+ 26.1 41.2 51 47.3 40.6 43.7 aromatics 57.5 17 21.7 2.7 3.2 0.9 oxygenates  8.8 13.3 15.6 3.1 1.2 0.4 CO 0.1 1.7 1.8 4 5.2 3.7 CO2 5.3 13.4 4.5 13.9 15.1 12.3 To determine co-reagent concentration influence on products yield was used acetone. The results of co-reagent concentration influence are presented in Table 5. Conversion of pure acetone mainly leads to propane and aromatics formation. As the reaction was carried out in inert atmosphere of Ar. hydrogen that is necessary for alkanes formation was formed during the reaction via parallel reaction of intermediates including aromatization. As acetone concentration decreased in feed aromatics content in products also decreased down to 3.2 wt.% at 10 vol.% acetone in feed. Optimal acetone concentration was found to be 40 vol.% that 418provides the maximum yield of alkanes C4+ equel to ≈40 wt.% and 20 wt.% of aromatics. So the total amount of fuel hydrocarbons reached up to 60 wt.%. Composition of hydrocarbons С4+ obtained during ethanol with different co-reagents conversion is shown in figure 1. Depending on the nature of the co-reagent the aim fraction (C3+ hydrocarbons) may consist of different hydrocarbon classes: alkanes. olefins. aromatics. Concentration of alkanes correlates with concentration of aromatics – the more alkanes obtained the more aromatics formed. In consequence of aromatics products forming hydrogen is produced that consumed in the formation of alkanes from initial alcohol. Over Pt-Re catalyst the most probable source of hydrogen is aromatics according to Eq.4 3EtOH → 3CH2=CH2 → C6H6+3H2 (4)  Figure 1: Composition (wt.%) of hydrocarbons С4+ , T=350°С, 5 atm Ar, over Pt-Re/Al2O3 catalyst Earlier was found that during fatty acids triglycerides conversion over Pt/Al2O3 catalyst glycerol fragment take part in hydrocarbon chain growth forming alkanes with a number of carbon atoms exceeds the one in initial fatty acids. To check the phenomenon we converted the simplest ester – ethyl acetate. During its conversion products up to C9 were found as shown in Figure 2, that confirms the possibility of intermolecular cross-coupling of esters. The main product was C6 olefins fraction. The presence of hydrocarbons with odd number of carbon atoms in its hydrocarbon skeleton testifies that C2 and C1 fragments formed during hydrogenation of C-O bonds and decarboxylation respectively may interact.   Figure 2: Ethyl acetate conversion products, T=420°C, 5 atm Ar over Pt-Re/Al2O3 catalyst Investigations of Butylmethacrylate conversion over Pt-Re/Al2O3 catalyst under conditions similar to rapeseed oil conversion showed that Butylmethacrylate could be incorporated in mainly C3-C4 fraction but also C5-C7 fraction was obtained. Hydrocarbons C5-C7 yield was 14 wt.% that is lower than in example with ethyl acetate. This phenomenon may be explained that hydrogen interrupts carbon chain growth. As a result in hydrogen atmosphere it is possible to obtain lower quantity of cross-coupling products and hydrocarbons will contain lower number of carbon atoms than in inert atmosphere. 020406080100EtOH EtOH+iPrOH EtOH+nPrOH EtOH+Acetone EtOH+Glycerolwt.%aromaticsolefinsalkanes051015202530yield, wt.%oxygenates aromatics olefins alkanes419 Figure 3: Butylmethacrylate conversion products, T=330°C, 50 atm H2, 0,6 h-1 over Pt-Re/Al2O3 catalyst 4. Conclusions Acetone and glycerol were found to be the most prospective co-reagents with ethanol. Its addition increase the aim fraction yield of hydrocarbons C4-C12 up to 60 wt.%. Analysis of ethanol conversion products showed that among its hydrocarbons with even number of carbon atoms dominates. Addition of glycerol, acetone and propanol to ethanol leads to increasing of hydrocarbons with odd number of carbon atoms yield. Comparison of primary cross-coupling products (hydrocarbons C5. C7. C8) obtained via ethanol conversion and combined conversion of ethanol with C3 substrate (propanol, glycerol, acetone) showed that its yield increased by 100-1000 times. Acknowledgements The current research made with financial support of The Ministry of education and science of the Russian Federation via Federal target program “Researches and developments on priority directions of scientific-technological complex of Russia for 2014-2020”, unique number RFMEFI57514X0052.  References Ragauskas A.J., Williams C.K., Davison B.H., Britovsek G., Cairney J., Eckert C.A., Frederick W.J., Jr. Hallett J.P., Leak D.J., Liotta C.L., Mielenz J.R., Murphy R., Templer R., Tschaplinski T., 2006, The path forward for biofuels and biomaterials, Science, 311, 484–489. Gude V.G., Patil P., Martinez-Guerra E., Deng S., Nirmalakhandan N.,  2013, Microwave energy potential for biodiesel production, Sustainable Chem Process, 1:5 4. Tsodikov M.V., Kugel V.V., Yandieva F.A., Mordovin V.P., Gekhman A.E., Moiseev I.I., 2004, Stoichiometric and catalytic CO2 reductions involving TiFe-containing intermetallic hydrides, Pure Appl Chem 76, 9,1769 Tsodikov M.V., Yandieva F.A., Kugel V.Ya., Chistyakov A.V., Gekhman A.E., Moiseev I.I., 2008, Reductive dehydration of ethanol: A new route towards alkanes, Catal. Let., 121, 3-4, 199. Astruc D., 2011, The 2010 Chemistry Nobel Prize to R.F. Heck, E. Negishi, and A. Suzuki for palladium-catalyzed cross-coupling reactions, Anal Bioanal Chem, 399, 1811–1814 Tsodikov M. V., Murzin V. Yu., Chistyakov A. V., Yandieva F. A., Gubanov M. A., Zharova P. A., Shapovalov S. S., Tikhonova O. G., Pasynskii A. A., Paul S., 2014, Dumeignil F.The Direct Ethanol Conversion to Hydrocarbons over Pt-Containing Catalysts, Chemical Engineering Transactions, 37, 583-588 051015202530354045с1-с2 c3 c4 c5+С7 С6 С5yield, wt.%420

Cross-coupling of bio-oxygenates over heterogeneous catalysts

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Cross-coupling of bio-oxygenates over heterogeneous catalysts

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