A new nursery school in Milan was designed in the framework of a national research about low-energy buildings in temperate climates. The design of the case study started from a bioclimatic-approach, considering relationship between building envelope and sun path. In particular, orientation and morphology of the school are optimized (i.e. the building shapes improve solar control; classrooms and offices face South, services face North), the envelope is thermally efficient in both its opaque and transparent parts and overhangs are dimensioned to ensure solar gain in winter and to avoid direct solar radiation during summer season. A set of solutions for optimizing both energy efficiency and comfort conditions has been assessed. A floor radiant system, fed by a groundwater heat pump, has been foreseen and combined with a primary air ventilation system, equipped with heat recovery and managed by CO2 sensors. The school will be also equipped with opening window detectors and presence detectors, coupled by daylighting sensors, for controlling both illumination and thermal energy supply (hot water circulation in the radiant floor pipes and primary air cycle). Further, RE has been integrated in the design for hot water production by evacuated solar collectors placed on the roof of the higher block. As a result, a dynamic simulation made by VisualDOE software assessed 20 kWh/m² of energy heating demand: this value is below national standards foreseen from 2009, referring to the recent Italian implementation of the Energy Performance Building Directive (EPBD)