We have read with profound interest the article by Bastos
and colleagues entitled Histologic Analysis of Zafirlukast’s
Effect on Capsule Formation Around Silicone Implants.
We have truly enjoyed this study because it focuses on the
very important issue of ongoing research toward pharmacologic
therapy for the treatment of periprosthetic capsule
contracture. The latter has an incidence in the range of
0.5% to 50% [3]. Despite persistent clinical and laboratory
investigation, to date, no solution has been developed to
solve or prevent this problem
