Introduction : More than 800.000 people died every years from suicide, and in 2012
suicidal acts on 15-29 years old become the second most cause. Suicide by poison is
one of the most used, Warfarins role here aside from its therapeutical effect as
anticoagulant, and also as rodenticide in household often misused for a way to
suicide. This study is aimed to analyze the differences of macroscopic and
microscopics representation in lungs and small intestine on Wistar mouse after LD50
dan LD100 Warfarin administration.
Method : This is experimental analytic study, using total sample of 27 mouse, male
Rattus norvegicus as the sample. These 27 mouse will be divided into 3 group, 9
eachs. First group is administered LD50 Warfarin, second group is administered LD100
Warfarin, and the third group as control.
Result : there is no differences in macroscopic aspect of lung control group with
group LD50 dan LD100, in microscopic showed massive haemmorhage. On small
intestines there is differences from control group with LD50 dan LD100.
Conclussion : Toxic effect from warfarin showed in microscopic view of organs with
hemorrhage and destruction of its tissues.
Keyword : Warfarin, Wistar, Macroscopic and Microscopic view.
1. Staff of Forensic Department, Faculty of Medicine Diponegoro University
2. Staff of Pathologic Anatomy Departmen, Faculty of Medicine Diponegoro
University
3. Undergraduate Students, Faculty of Medicine Diponegoro University