Infant mortality, the death of a child under age one, is an important global public health issue. Although progress has been made, many countries still experience high levels of infant death. In South Africa, significant poverty and inequality have led to one of the highest rates of sudden unexpected infant death in the world. A literature search was conducted to identify published literature about programs, policies, and interventions that aim to decrease sudden infant death. The results of the literature review were used to propose a plan for reducing infant deaths in South Africa. The proposed plan includes an infant death investigation protocol, healthcare provider and parental education, an infant screening system, bassinet distribution, and a public health campaign. The proposed plan is designed to reach the families most in need of support and resources to keep infants safe