In view of the fire safety requirements of urban rail transit, the technical optimization and domestic application research of fire alarm system was focused. By analyzing the environmental characteristics and equipment status of rail transit, systematic research on the integrated design and domestic substitution of fire alarm equipment was carried out. Based on the particularity of the scene, an innovative integrated design scheme was proposed, and multi-dimensional perception and rapid linkage response of fire signals were achieved through module integration and intelligent algorithm optimization. Meanwhile, the path of large-scale application of domestic equipment was explored and the effectiveness was verified in cost control, technology adaptation and industrial autonomy. The results show that the integrated design significantly improves the system coordination and early warning reliability; the application of domestic equipment not only reduces construction and operation and maintenance cost, but also promotes independent innovation and industrial upgrading in fire protection technology