Disclosure: P. Kempegowda: None. S. Broughton: None. A. Ling Jie Yee: None. S. Ali Baig: None. E. Blendis: None. E. Armeni: None. D. Collaboration: None. Background and Objective: Clinicians should have an awareness of the impact PCOS has on body image. However, research on this area is limited. This study explored the association between body image and quality of life, depression, anxiety, acne, and hirsutism in women with PCOS. Methods: This prospective study was conducted in the UK from July 2023 to November 2024. Women aged ≥18 years with PCOS diagnosis based on the Rotterdam criteria were eligible. Recruitment was conducted via social media and specialist PCOS clinics in Birmingham and London, UK. Eligible women were invited to complete an online survey which included: 1.Sociodemographic and Clinical Data: Age, BMI, ethnicity, education, employment, and socioeconomic status (assessed via the Townsend deprivation index). 2.Body Image: using the MBSRQ-AS, which evaluates appearance evaluation (AE), appearance orientation (AO), body areas satisfaction (BAS), overweight preoccupation (OP), and self-classified weight (SW). 3.Psychological Distress: using HADS (anxiety and depression subscales). 4.Eating Behaviours: using the SCOFF questionnaire for disordered eating. 5.Hirsutism: using modified Ferriman-Gallwey (mFG) score. 6.PCOS-Specific Quality of Life: using PCOS-Q. Statistical Analysis: Descriptive statistics were used to summarise demographic and clinical characteristics. Welch’s t-test compared MBSRQ-AS component scores with sex-matched norms. Ordinal logistic regression was performed to assess associations between MBSRQ-AS components and age, ethnicity, Townsend index, body mass index (BMI), anxiety and depression (HADS), hirsutism (mFG), eating disorder (SCOFF), and quality of life (PCOS-Q). Significance was set at p<0.05. Results: The cohort (n=173) had a median age of 30 years (IQR 25-35) and a mean BMI of 33.0 ± 9.5 kg/m². Compared to sex-matched norms, participants exhibited lower appearance evaluation and body areas satisfaction scores (p<0.001), indicating greater body dissatisfaction and higher overweight preoccupation scores. Poorer appearance scores in MBSRQ-AS evaluation were associated with depression (OR 1.21, p<0.001), anxiety (OR 1.12, p=0.006), disordered eating (OR 1.43, p=0.011), and weight-related PCOS distress (OR 1.13, p<0.001) independent of age, ethnicity, and deprivation. Similarly, lower body areas satisfaction was independently associated with Hirsutism (OR 1.06, p=0.006), while disordered eating was strongly associated with overweight preoccupation (OR 2.46, p<0.001). All associations were independent of age, ethnicity, and deprivation. Conclusions: Women with PCOS exhibit heightened body image concerns, strongly correlated with psychological distress, disordered eating, and metabolic features. These findings underscore the need for integrative care addressing both metabolic and psychological aspects of PCOS management.Presentation: Sunday, July 13, 202
