Taxanes from the roots of Taxus x media cv Hicksii

Abstract

The plants of genus taxus commonly known as yew tree have been used since the ancient times for their magic, poisonous and pharmacological properties. Studies devoted to chemical constitution of extracts of several Taxus genera have been extensively developed during the last years, according to the well documented anticancer activity of taxol. The bark of several yew species has been thoroughly investigated, but very few studies have been done on the constituents of roots. The roots of an ornamental variety of yew (T. x media cv Hicksii) gave a series of taxane and abeotaxane pseudoalkaloids. Both N-alkylated O (5) esters (taxines) and N-acylated O (13) esters (Taxols) were isolated, some of them in glycosidic form. Besides known compounds, some new taxines, taxols and abeotaxanes were isolated and their structures fully elucidated

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