The antiproliferative effect of serotonin-reuptake inhibitors (SSRI) and serotonin antagonists has been demonstrated in
prostate tumors. Since Hypericum perforatum components act as serotonin-reuptake inhibitors and exert cytotoxic effects on
several human cancer cell lines, in this work we analyzed the effect of a treatment with Hypericum perforatum extract (HPE) on
the growth of human prostate cancer cells in vitro and in vivo. This study highlighted a significant reduction of tumor growth
and number of metastasis suggesting that this natural compound may be useful in the treatment of prostate cancer
