Camele I.

Elshafie, H.S

Sakr S.H.

Sakr S. H.

Elshafie, H. S

CAMELE, Ippolito Natale

Archivio della Ricerca - Università della Basilicata

The Eleventh International Environmental Science Conference  Basic Science and their Applications for Environmental protection and renewable development Faculty of Science, Zagazig University Zagazig, Egypt at 17.07.2016  Synthesis, spectroscopic characterization and biological studies of mixed ligand complexes of gemifloxacin drug and glycine with Sn(II), Zn(II) and Ce(IV) S.H. Sakr1,2, H.S. Elshafie2, I. Camele2 and S.A. Sadeek1,* 1 Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt;  2School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell’Ateneo Lucano, 85100 Potenza, Italy.  ∗ Corresponding author. Tel.: +20 01220057510; fax: +20 0553208213. E-mail address: s_sadeek@zu.edu.eg  Abstract Three novel mixed ligand metal complexes have been synthesized by the reaction of metal salt with gemifloxacin in the presence of glycine (0.5:0.5:0.5 molar ratio). The coordination possibility of the two ligand towards metal ions have been proposed in the light of elemental analysis. molar conductance. spectral (IR, UV–Vis and 1H NMR) and  magnetic studies. Results suggest that gemifloxacin and glycine interact with the metals as a bidentate ligands. Electronic and magnetic data proposed the octahedral structure for all complexes under investigation. Antibacterial screening of the compounds was carried out in vitro against two G+ve bacteria Clavibacter michiganensis and Bacillus megaterium and two G-ve bacteria Escherichia coli and Xanthomonas campestris. Antifungal activity was performed in vitro against Rhizoctonia solani, Sclerotinia sclerotiorum, Aspergillus niger, Botrytis cinerea and Penicillium digitatum. The ligand and its complexes were also screened for their antioxidant activity. Results showed that some metal complexes showed more biological efficiency than the parent gemifloxacin drug.  Keywords: Gemifloxacin; 1HNMR; Minimum Inhibitory Concentrations for fungicidal activity; Antioxidant activity.   

English

Synthesis, spectroscopic characterization and biological studies of mixed ligand complexes of gemifloxacin drug and glycine with Sn(II), Zn(II) and Ce(IV).

Synthesis, spectroscopic characterization and biological studies of mixed ligand complexes of gemifloxacin drug and glycine with Sn(II), Zn(II) and Ce(IV).

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Archivio della Ricerca - Università della Basilicata