CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
research
Serotonin system implication in L-DOPA-induced dyskinesia: from animal models to clinical investigations
Authors
MANOLO CARTA
ELISABETTA TRONCI
Publication date
1 January 2014
Publisher
'Frontiers Media SA'
Doi
Cite
View
on
PubMed
Abstract
In the recent years, the serotonin system has emerged as a key player in the induction of l-DOPA-induced dyskinesia (LID) in animal models of Parkinson's disease. In fact, serotonin neurons possess the enzymatic machinery able to convert exogenous l-DOPA to dopamine (DA), and mediate its vesicular storage and release. However, serotonin neurons lack a feedback control mechanism able to regulate synaptic DA levels. While in a situation of partial DA depletion spared DA terminals can buffer DA released from serotonin neurons, the progression of DA neuron degeneration impairs this protective mechanism, causing swings in synaptic DA levels and pulsatile stimulation of post-synaptic DA receptors. In line with this view, removal of serotonin neurons by selective toxin, or pharmacological silencing of their activity, produced complete suppression of LID in animal models of Parkinson's disease. In this article, we will revise the experimental evidence pointing to the important role of serotonin neurons in dyskinesia, and we will discuss the clinical implications. © 2014 Carta and Tronci
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Frontiers - Publisher Connector
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 05/06/2019
Frontiers - Publisher Connector
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 15/05/2017
Archivio istituzionale della ricerca - Università di Cagliari
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:iris.unica.it:11584/96144
Last time updated on 12/11/2016