Toxoplasma gondii is a protozoan that causes toxoplasmosis, a disease whose severity depends on the immune status of the host. Immunosuppressed patients, such as those with HIV/AIDS, are especially vulnerable, since this parasite can cause severe and potentially fatal clinical pictures. The aim of the study was to analyze how T. gondii affects immunocompromised patients and how immune impairment influences the severity of clinical manifestations. Through a literature review (2019-2024) in databases such as SciELO, Scopus and PubMed, it was determined that the impaired immune status facilitates the dissemination of the parasite, causing multi-organ infections. Toxoplasma encephalitis is common, characterized by headache, fever, convulsions and risk of deat
